Results 71 to 80 of about 2,782,243 (307)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
SUPERMARKET CHARACTERISTICS AND OPERATING COSTS IN LOW-INCOME AREAS [PDF]
Whether the poor pay more for food than other income groups is an important question in food price policy research. Stores serving low-income shoppers differ in important ways from stores that receive less of their revenues from Food Stamp redemptions ...
Behl, Ajay S. +2 more
core +1 more source
, 2015 We describe statistical and coherence properties of the radiation from x-ray free electron lasers (XFEL) operating in the post-saturation regime. We consider practical case of the SASE3 FEL at the European XFEL.
Schneidmiller, E. A., Yurkov, M. V.
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
CHARACTERISTICS AND RESIDENTIAL PATTERNS OF ENERGY-RELATED WORK FORCES IN THE NORTHERN GREAT PLAINS [PDF]
The socioeconomic characteristics of construction and operating work forces at energy related facilities in the Northern Great Plains were analyzed. A primary interest was to explain differences in local hire rates and settlement patterns on the basis of
Leistritz, F. Larry +2 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Journal of Statistical Software, 2016 The R package gsbDesign provides functions to evaluate the operating characteristics of Bayesian group sequential clinical trial designs. More specifically, we consider clinical trials with interim analyses, which compare a treatment with a control, and ...
Florian Gerber, Thomas Gsponer
doaj +1 more source
Tubular chemical reactors: the "lumping approximation" and bifurcation of oscillatory states [PDF]
, 1974 We study axial heat and mass transfer in a highly diffusive tubular chemical reactor in which a simple reaction is occurring. Singular perturbation techniques are used to derive approximate equations governing the situation.
Cohen, Donald S., Poore, Aubrey B.
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source