Results 71 to 80 of about 13,905,908 (327)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Annual Energy Efficiency Analysis and Experiment Research on Variable Speed Air-Conditioner Based on Climatic Factors

Zhileng xuebao, 2015
Research on the annual performance factor specified in variable speed air-conditioner energy efficiency standard GB21455-2013. A variable speed air-conditioner was studied, two operating modes were established combining with typical meteorological year ...
Li Tang, Wang Fang, Qu Yan, Meng Zhaofeng, Wang Yu, Zhao Yale, Guo Chao   +6 more
doaj   +2 more sources

Mathematic model of three-phase induction machine connected to advanced inverter for traction system for electric trolley

Anais da Academia Brasileira de Ciências, 2013
This paper establishes a mathematical model of induction machine connected to a frequency inverter necessary to adjust the electric motor drive. The mathematical model based on the Park's theory allows the analysis of the whole spectrum (electric car ...
LIVIU S. BOCÎI, VALENTIN MÜLLER
doaj  

Foundation Expenses and Compensation: Interim Report 2005 [PDF]

, 2005
Examines the 10,000 largest foundations and identifies characteristics and operating styles that affect levels of expenses and compensation, including foundation type, size, staffing, scope of activity, and direct charitable ...
Elizabeth T. Boris, Loren Renz, Mark A. Hager   +2 more
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

OPERATING CHARACTERISTICS OF POROUS FLOATING – RINGJOURNAL BEARINGS OPERATING WITH AN IMPROVEDBOUNDARY CONDITIONS

Journal of Engineering, 2007
The static characteristics of porous floating ring journal bearing under hydrodynamic lubrication condition when operating with an improved boundary conditions are theoretically analyzed.
Basim A. Abass, Alaa' M. Hussan, Lekaa' Hameed   +2 more
doaj   +3 more sources

A simplified method to approximate a ROC curve with a Bézier curve to calculate likelihood ratios of quantitative test results

MethodsX, 2020
In order to calculate likeli hood ratios (LR) values for quantitative test results, a distribution-independent algorithm based on Bézier curves is proposed.
Walter Fierz
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of management strategies for the operation of high-speed railways in China [PDF]

, 2002
High-Speed Train (HST) operations have recently been introduced in rail passenger transportation markets worldwide. Although the technologies for such operations have levelled at speeds of around 300 km/h, the operating parameters to be adopted in each ...
Ferreira, Luis, Han, Baoming M., Sun, Q.X., Wong, Wing-gun, Zhu, X. N.   +4 more
core   +2 more sources