Results 111 to 120 of about 469,931 (305)

Computational Modelling of Tyres Considering Operating and Safety Requirements

open access: yes, 2008
This contribution deals with the structural concept of tyres considering operating and safety aspects. Results obtained from experimental modelling of tyres considering operating and functional aspects are an essential condition of generation of "correct"
Jan Krmela
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Vibration-powered sensing system for engine condition monitoring

open access: yes
Condition monitoring is becoming an established technique for managing the maintenance of machinery in transport applications. Vibration energy harvesting allows wireless systems to be powered without batteries, but most traditional generators have been ...
Weddell, Alex S.   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A RESEARCH ON THE PERFORMANCE DEGRADATION OF COMBINED ROTOR CONSIDERING CRACK IN DISK

open access: yesJixie qiangdu, 2020
The performance degradation of combined rotor with crack of the disk is one of the significant reasons which cause malfunctions and accidents of gas turbine,while rules of performance degradation are still unclear.
SHAO ShiCong   +3 more
doaj  

A Study of Non-stationary Signal Processing for Machinery Condition Monitoring

open access: yes
Machinery condition monitoring techniques are carried out based on the knowledge of the characteristics of signals obtained from a machine or plant. These signals are often non stationary signals whose frequency changes over time due to the time-varying ...
Zhen, Dong
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Toward least-privilege isolation for software

open access: yes, 2009
Hackers leverage software vulnerabilities to disclose, tamper with, or destroy sensitive data. To protect sensitive data, programmers can adhere to the principle of least-privilege, which entails giving software the minimal privilege it needs to ...
Bittau, A., Andrea Bittau
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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