Results 61 to 70 of about 1,950,867 (244)

Тактика лечения радикулярной кисты, расположенной в области зуба, имеющего сложное анатомическое строение (зуб в зубе)

open access: yesЭндодонтия Today, 2020
Radicular cyst treatment mostly requires surgical approach. But there are cases where this method is not effective for example when the radicular cyst is present at the apex of the anatomically difficult configuration of the «dens in dente» tooth ...

doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

MAGNETIC FORCE MICROSCOPE IMAGE EVALUATION OF MAGNETIC IRON OXIDE FLOPPY DISC WITH VARIOUS LIFT HEIGHTS [PDF]

open access: yes, 2020
Magnetic Force Microscope Image Evaluation of Magnetic Iron Oxide Floppy Disc with Various Lift Heights. One of the advantages of Scanning Probe Microscopes (SPM) or better known as the Atomic Force Microscope (AFM) is its ability to "see" in detail at ...
Mardiyanto, Mardiyanto   +2 more
core   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Heads up in Surgery: The Ergonomics Revolution for Vitreo-retina Surgeons with Review of Literature

open access: yesTNOA Journal of Ophthalmic Science and Research
Work-related musculoskeletal disorders (MSDs) are ubiquitous among vitreo-retina surgeons due to prolonged static posture, microscope use, and fine motor demands.
Harshal Sahare   +3 more
doaj   +1 more source

Use of dental operating microscope in non ⁃surgical endodontic treatment

open access: yes口腔疾病防治, 2017
Dental operating microscope is recommended to complicated root canal therapy, for it could provide in⁃ creased lighting and superior magnification, so that the survival rate of tooth is highly increased. More refined access of cavity preparation, canal
GAO Yan, JIANG Xiaoqiong
doaj   +1 more source

Practical use of digital cameras for microphotography through the operating microscope

open access: yes, 2003
A practical use of personal digital cameras for taking digital photographs in the microsurgical field through an operating microscope is described.
Shafighi, Maziar   +3 more
core  

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