Results 41 to 50 of about 2,638,696 (303)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autonomous Control Strategy for Microgrid Operating Modes Smooth Transition

IEEE Access, 2020
Microgrid transition between standalone and grid-connected modes is a promising alternative to provide the grid with increasing flexibility and availability. However, transition smoothness relies heavily on control topologies and corresponding parameters,
Yaran Li, Long Fu, Ke Meng, Zhao Yang Dong, Kashem Muttaqi, Wenli Du   +5 more
doaj   +1 more source

On Modes of Operation

Proceedings of the Amsterdam Colloquium, 1995
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openaire   +1 more source

Extracting Operating Modes from Building Electrical Load Data: Preprint [PDF]

, 2012
Empirical techniques for characterizing electrical energy use now play a key role in reducing electricity consumption, particularly miscellaneous electrical loads, in buildings.
Polese, L. G., Smith, J., Frank, S., Sheppy, M., Rader, E.   +4 more
core  

Correction to “Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases”

, 2016
Correction to “Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and ...
Karim El Kirat (1812493), Sandrine Morandat (1812490), M. Isabel Garcia Moreno (1812499), David Deniaud (1431271), Sébastien Vidal (1697773), Susan E. Matthews (1812496), Yoan Brissonnet (1618552), Sergej Šesták (1618558), Carmen Ortiz Mellet (1710091), Sébastien G. Gouin (1812487)   +9 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Spatial pattern and influencing factors of elderly care facilities: a case study from in Fujian Province, China

Journal of Asian Architecture and Building Engineering
The spatial layout and supply of elderly care facilities (ECFs) have become key issues constraining the fairness and accessibility of elderly care services.
Junming Zheng, Yashan Chen
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source