Results 41 to 50 of about 3,152,811 (245)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Field-Scale Evaluation of Seed Placement Quality in No-Till Sunflower Sowing: Operating Speed, Soil Moisture, and Compliance with Seeder Settings

AgriEngineering
Achieving stable seed placement under No-Till conditions remains challenging because the seeding units operate directly in undisturbed soil with spatially variable properties and surface residues.
Yordan Stoyanov, Galya Hristova
doaj   +1 more source

The (in)efficiency of trams and buses in Brussels: a fine geographical analysis

Brussels Studies, 2008
At a time when mobility in Brussels is becoming increasingly critical from the standpoints of the environment and efficiency, this article gives a detailed and exhaustive analysis of the geography of traffic conditions affecting the trams and buses of ...
Xavier Courtois, Frédéric Dobruszkes
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Columbia River Treaty: Principles and procedures for preparation and use of hydroelectric operating plans for Canadian Treaty storage

, 2020
COLUMBIA RIVER TREATY PRINCIPLES AND PROCEDURES FOR PREPARATION AND USE OF HYDROELECTRIC OPERATING PLANS FOR CANADIAN TREATY STORAGE October 2003Principles and Procedures for Preparation and Use of Hydroelectric Operating Plans For Canadian Treaty ...
Columbia River Treaty Operating Committee;
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effect of wind on operating cost based cruise speed reduction for delay absorption

, 2013
En route speed reduction can be used for air traffic flow management (ATFM), e.g., delaying aircraft while airborne or realizing metering at an arrival fix.
Delgado, L., Prats Menéndez, Xavier, Prats, X., Delgado Muñoz, Luis   +3 more
core   +1 more source

Evaluating Effect of Operating Speed on Crashes of Rural Two-Lane Highways

Journal of Advanced Transportation, 2023
Crashes on a roadway are influenced by various factors, including but not limited to road geometries, traffic volume, and environmental conditions. Among these factors, traffic volume and segment length are commonly used to predict crashes. Recently, the
Fahmida Rahman, Xu Zhang, Mei Chen
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source