Results 91 to 100 of about 27,924,758 (382)

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Methodological approach to quantitative assessment of the security of open operating systems AS of the Internal Affairs Bodies

open access: yesВестник Дагестанского государственного технического университета: Технические науки
Objective. The article considers the provisions of the fuzzy logic approach in relation to the method of quantifying the security of open operating systems (OS) of automated systems of the internal affairs bodies of the Russian Federation (AS of the ...
A. I. Yangirov   +3 more
doaj   +1 more source

OPERATING SYSTEMS

open access: yes, 2020
An Operating System is a program that acts as an intermediary between a user of a computer and the computer hardware. Objectives of Operating System are: Convenience: - for small PC’s. Efficiency: - for large, shared multi user systems since they are expensive.
openaire   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Introduction to Operating Systems [PDF]

open access: yes, 2019
The aims of this chapter are to introduce the following: To provide a brief history of operating system development. To look briefly at some commonly used operating systems DOS and Windows. Unix and X-Windows. VMS and Open VMS.
Jane Sleightholme, Ian Chivers
openaire   +4 more sources

Usability Analysis of a Novel Biometric Authentication Approach for Android-Based Mobile Devices

open access: yesJournal of Telecommunications and Information Technology, 2014
Mobile devices are widely replacing the standard personal computers thanks to their small size and userfriendly use. As a consequence, the amount of information, often confidential, exchanged through these devices is raising.
Vincenzo Conti   +3 more
doaj   +1 more source

On the definition of a theoretical concept of an operating system [PDF]

open access: yes, 2010
We dwell on how a definition of a theoretical concept of an operating system, suitable to be incorporated in a mathematical theory of operating systems, could look like.
Bergstra, J. A., Middelburg, C. A.
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Improving the Energy Efficiency of the MANTIS Kernel [PDF]

open access: yes, 2007
Event-driven operating systems such as TinyOS are the preferred choice for wireless sensor networks. Alternative designs following a classical multi-threaded approach are also available.
Duffy, Cormac   +3 more
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

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