Results 41 to 50 of about 895,674 (297)

CFFS: A Persistent Memory File System for Contiguous File Allocation With Fine-Grained Metadata

open access: yesIEEE Access, 2022
Extensive research on persistent memory (PM)-aware file systems has led to the development of numerous methods for improving read/write throughput. In particular, accessing or modifying file contents in a similar manner to the memory operations through ...
Jen-Kuang Liu, Sheng-De Wang
doaj   +1 more source

History states of systems and operators [PDF]

open access: yesPhysical Review A, 2018
We discuss some fundamental properties of discrete system-time history states. Such states arise for a quantum reference clock of finite dimension and lead to a unitary evolution of system states when satisfying a static discrete Wheeler-DeWitt-type equation.
Boette, Alan Pablo, Rossignoli, Raúl
openaire   +6 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Methodological approach to quantitative assessment of the security of open operating systems AS of the Internal Affairs Bodies

open access: yesВестник Дагестанского государственного технического университета: Технические науки
Objective. The article considers the provisions of the fuzzy logic approach in relation to the method of quantifying the security of open operating systems (OS) of automated systems of the internal affairs bodies of the Russian Federation (AS of the ...
A. I. Yangirov   +3 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Methodology to evaluate performance of the I/O systems on High Performance Computers

open access: yesJournal of Computer Science and Technology, 2018
Extracting the performance characteristics of the different I/O configurations of the I/O system. These activities are independent. The characterization of application is done off-line and the application I/O model can be applied to analyze different target ...
Sandra Méndez, Dolores Rexachs
doaj  

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