Results 61 to 70 of about 6,223 (252)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Extraction of circuit parameters using multi-objective genetic algorithm for design of non-linearly compensated operational amplifiers [PDF]

open access: yesمجله مدل سازی در مهندسی, 2019
In this paper, a CMOS operational amplifier (op-amp) for applications requiring a bandwidth several hundreds of MHz will be designed and optimized. The op-amp is two-stage and compensated by current buffer and a Miller capacitor.
Esmaeel Ranjbar   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Design of Analog Signal Processing Applications Using Carbon Nanotube Field Effect Transistor-Based Low-Power Folded Cascode Operational Amplifier

open access: yesJournal of Nanotechnology, 2018
Carbon nanotube (CNT) is one of the embryonic technologies within recent inventions towards miniaturization of semiconductor devices and is gaining much attention due to very high throughput and very extensive series of applications in various analog ...
Varsha S. Bendre   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design Low Power 130mW Pipeline ADC With Speed 80 MSPS 8-bit

open access: yes, 2009
This paper describes a pipeline analog-to-digital converter is implemented for high speed camera. In the pipeline ADC design, prime factor is designing operational amplifier with high gain so ADC have been high speed.
afandi, Hamzah
core  

Design of low-voltage operational amplifier

open access: yes, 2021
This work deals with the design of operational amplifier with extremely low supply voltage and low power consumption. In the theoretical part is presented theory dealing with the structure and design of operational amplifier.
Sysel, Jan
core  

OTA a wide common mode low power

open access: yesIngeniería Investigación y Desarrollo, 2016
This paper presents the design of an operational transconductance amplifier OTA operating in sub-threshold region for low power consumption. Simulations were performed in SYNOPSYS tools program for a 180nm technology.
Héctor Iván Gómez-Ortiz   +2 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

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