Results 41 to 50 of about 5,022 (254)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Research and improvement of operational amplifier stability in capacitive sensor driver circuits
Технологія та конструювання в електронній апаратурі, 2008 It has been shown that the instability of operational amplifiers in capacitive driver circuits is caused by a significant phase shift in the negative feedback loop, which leads to oscillation processes.
Z. Yu. Hotra +2 more
doaj
Mokslas: Lietuvos Ateitis, 2013 The article offers the analysis of operational amplifier parameter changes, when circuits are scaled from 0.18 μm to 65 nm CMOS technology. Two two-stage operational amplifiers were designed for this purpose: first uses n-MOS input differential pair ...
Karolis Kiela, Marijan Jurgo
doaj +1 more source
Reduction of operational amplifiers finite gain effects in switched-capacitor biquads [PDF]
Serbian Journal of Electrical Engineering, 2005 A combined approach for reducing the errors in the pole frequency f p, the pole Q - factor Qp and the magnitude at the pole frequency Hp, of switched capacitor biquads is presented.
Radev Nikolay, Ivanov Kantcho
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A SWITCHED MULTIDIFFERENTIAL OPERATIONAL AMPLIFIER FOR A MULTICHANNEL MEASURING SYSTEM
Измерение, мониторинг, управление, контрольBackground. The purpose of this study is to design an amplifier that allows differential conversion of several input voltages with the possibility of multiplexing them, as well as having a lower zero offset voltage and a high commonmode attenuation ...
Sergey V. Fedorov
doaj +1 more source