Results 61 to 70 of about 5,022 (254)

The metrological aspects of converters based on operational amplifiers used to measure the electrical parameters of oxide coatings

Известия высших учебных заведений. Поволжский регион:Технические науки, 2023
Background. The study is devoted to the issue of improving the accuracy of automated measuring instruments for the electrical parameters of oxide coatings.
Ekaterina A. Pecherskaya, Artem V. Volik, Timur O. Zinchenko, Igor' N. Kamardin, Dmitriy V. Artamonov, Sergey A. Gurin   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Generation of equivalent forms of operational trans-conductance amplifier-RC sinusoidal oscillators: the nullor approach

The Journal of Engineering, 2014
It has been shown in two earlier papers published from this study that corresponding to a given single-operational trans-conductance amplifier (single-OTA)-RC and dual-OTA-RC sinusoidal oscillators, there are three other structurally distinct equivalent ...
Raj Senani, Manish Gupta, Data Ram Bhaskar, Abdhesh Kumar Singh   +3 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Active-Only Sinusoidal Oscillator Circuits

Active and Passive Electronic Components, 2001
Two new active-only sinusoidal oscillator circuits are proposed. The first circuit uses one current feedback operational amplifier (CFOA) and four operational transconductance amplifiers (OTAs). The second circuit uses only four OTAs.
Muhammad Taher Abuelmaatti, Muhammad Ali Al-Qahtani   +1 more
doaj   +1 more source

Design of input stage amplifier circuit for power operational amplifiers

Dianzi Jishu Yingyong, 2019
An input stage amplifier is designed for a power operational amplifier based on 70 V high voltage bipolar technology. The amplifier circuit implements a differential telescopic cascode pair using p-type JFETs.
Wang Yongyong, Yang Fashun, Wang Decheng, Hu Rui, Ma Kui   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mutator Circuit for Memcapacitor Emulator Using Operational Transconductance Amplifiers

Elektronika ir Elektrotechnika
In recent years, interest in memelements, including memcapacitors, has increased significantly following the realisation of memristors. This paper presents the design and implementation of a memcapacitor circuit based on operational transconductance ...
Mustafa Konal, Fırat Kacar
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source