Results 91 to 100 of about 86,251 (282)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
From moral welfarism to technical non-welfarism : A step back to Bentham’s felicific calculus of its members [PDF]
A focus on the information used in Bentham’s felicific calculus sheds new light on the contemporary debate in normative economics opposing non-welfarism to welfarism. As a utilitarian, Bentham is de facto welfarist on a moral sense.
A. Baujard
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Program equivalence for a concurrent lambda calculus with futures [PDF]
, 2006 Reasoning about the correctness of program transformations requires a notion of program equivalence. We present an observational semantics for the concurrent lambda calculus with futures Lambda(fut), which formalizes the operational semantics of the ...
Niehren, Joachim +3 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Universal Concurrent Constraint Programing: Symbolic Semantics and Applications to Security [PDF]
, 2008 International audienceWe introduce the Universal Timed Concurrent Constraint Programming (utcc) process calculus; a generalisation of Timed Concurrent Constraint Programming.
Olarte, Carlos, Valencia, Frank D.
core +1 more source
The Abel summation of the Kontorovich-Lebedev integral representation [PDF]
Opuscula Mathematica, 2005 A new result on the summation of the Kontorovich–Lebedev integral representation in the sense of Abel mean is given.
Petru A. Cojuhari, Alexander M. Gomilko
doaj
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source