Results 111 to 120 of about 6,665 (300)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An Operational Semantics for StAC, a Language for Modelling Long-running Business Transactions
, 2004 This paper presents the StAC language and its operational semantics. StAC (Structured Activity Compensation) is a business process modelling language and a distinctive feature of the language is its support for compensation.
Ferreira, Carla +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Making the unobservable, unobservable
, 2009 Behavioural equivalences of various calculi for modelling distributed systems differ significantly because the properties which can be observed through interaction depend heavily upon their mode of communication.
Julian Rathke +4 more
core +1 more source
Stress-Strain State of an Orthotropic Rectangular Plate Simply Supported on All Sides
Structural Mechanics of Engineering Constructions and Buildings. In view of the wide application of composite structures in engineering practice, an important task is to study their stress-strain state under the action of various loads.
Kamil F. Shagivaleev +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2008 The paper proposes a variation of simulation for checking and proving contextual equivalence in a non-deterministic call-by-need lambda-calculus with constructors, case, seq, and a letrec with cyclic dependencies. It also proposes a novel method to prove
Schmidt-Schauß, Manfred +1 more
core
On the operational calculus for groups of operators
, 1970 We study some compactness properties of the natural operational calculus for groups of operators.
Shmuel Kantorovitz
core +1 more source