Results 41 to 50 of about 2,204,053 (310)

Maine Medical Center Quality and Safety Storyboards: Operational Excellence as Platform for Improvement [PDF]

open access: yes, 2019
Physician and other healthcare learners and clinicians must prepare to assume an active role in the design, implementation, and improvement of emerging models of health care delivery while concurrently improving quality, workflow efficiency and safety ...

core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Unbounded products of operators and connections to Dirac-type operators

open access: yesBulletin des Sciences Mathématiques, 2014
Let $A$ and $B$ be two densely defined unbounded closeable operators in a Hilbert space such that their unbounded operator products $AB$ and $BA$ are also densely defined. Then all four operators possess adjoints and we obtain new inclusion bounds for the operator product closures $\bar{A} \bar{B}$ and $\bar{AB}$ in terms of new relations among the ...
Gustafson, Karl, Mortad, Mohammed Hichem
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transformation of Urban Sewer Network Management through GIS: Enhancing Operational Efficiency, Revenue Generation, and Environmental Sustainability [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Effective management and expansion of sewer networks are vital for sustainable urban development and environmental protection. Traditional approaches, often reliant on manual surveys and assessments, suffer from inefficiencies, high labor costs, and ...
A. Azizi, S. Davarpanah, K. Afzal
doaj   +1 more source

Study of operational losses of block raw materials

open access: yesТехнічна інженерія, 2023
The work investigates operational losses depending on the method of mining and substantiates the methods of control and management of the quality of the natural stone massif.
S.S. , O.M. , G.V. , A.H., O.A.
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Reconstruction Plan of Small-Spacing Interchange Connection Sections on Expressway: A Case Study of Xinlong‒Gangkou Interchange on Zhongshan‒Jiangmen Expressway

open access: yesZhongwai Gonglu
The plan design for the small-spacing interchange connection on the expressway directly affects operational efficiency and driving safety. To achieve the conversion of traffic flow between different expressways, this study explored the reconstruction ...
JIE Qiang, FU Xinsha
doaj   +1 more source

Numerical simulation of a mechanical flocculation process with multi-chambers in series

open access: yesWater Science and Technology, 2023
A mechanical flocculation system with multi-chambers in series is commonly used as the advanced phosphorus removal technology for wastewater treatment. This work aims to numerically investigate the inner states and overall performance of industrial-scale
Jie Zong   +5 more
doaj   +1 more source

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