Results 101 to 110 of about 9,641,659 (250)

Corporate marketing potential assessment model in the context of operational, tactical and strategic levels [PDF]

Marketing i Menedžment Innovacij, 2013
The aim of the article. The aim of this research is to develope the mathematic model structure of result-oriented evaluation of corporate marketing potential in the context of management potential levels (operational, tactical and strategic) that takes ...
L.V. Potrashkova
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bayesian Methods for Measuring Operational Risk [PDF]

The likely imposition by regulators of minimum standards for capital to cover 'other risks' has been a driving force behind the recent interest in operational risk management.
Carol Alexander
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Real-time dose prediction for Artemis missions

Journal of Space Weather and Space Climate
As large solar energetic particle (SEP) events can add significant radiation dose to astronauts in a short period of time and even induce acute clinical responses during missions, they present a concern for manned space flight operation.
Hu Shaowen, Barzilla Janet E., Núñez Marlon, Semones Edward   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fuzzy bi-objective optimization model for multi-echelon distribution network

Ratio Mathematica, 2014
It is important for modern businesses to search the ways for continuous improvement in performance of their supply chains. The effective coordination and integrated decision making across the supply chain enhances the performance among its various ...
Kanika Gandhi, P.C. Jha
doaj  

Spatial and seasonal accessibility of marine research weather windows in the polish exclusive economic zone

Scientific Reports
This study focuses on analysing weather windows in the Polish Exclusive Economic Zone of the southern Baltic Sea, assessing the spatial and temporal variability of sea conditions that influence the accessibility of marine areas for research and offshore ...
Maria Kubacka, Dariusz Barbucha, Adam Krężel, Juliusz Gajewski   +3 more
doaj   +1 more source