Results 111 to 120 of about 409,532 (317)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Construction of a European Institutional Model for Managing Operational Cooperation at the EU's External Borders: Is the FRONTEX Agency a decisive step forward? CEPS CHALLENGE Paper, No. 6, 22 March 2007 [PDF]
, 2007 Within the context of the fifth enlargement of the EU, the increasing securitisation of JHA policies and the establishment of an area of freedom, security and justice, the issue of integrated border management (IBM) has become crucial since 2001 ...
Jorry, Hélène.
core
Strategic and operational perspectives of SME brand management: A typology
, 2019 This paper seeks a holistic understanding of brand management in SMEs, incorporating both strategic and operational perspectives. The aim of the study is theory-building, contributing a typology of SME brand management.
M'zungu, Simon +2 more
core +1 more source
A Novel Slacks-Based Interval DEA Model and Application
AxiomsThis paper proposes a novel slacks-based interval DEA approach that computes interval targets, slacks, and crisp inefficiency scores. It uses interval arithmetic and requires solving a mixed-integer linear program.
Manuel Arana-Jiménez +4 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Operation, operative or operational production management
, 2009 The integration of determinant functions of value forming chain is solved by the subsystem of operational control of manufacturing. It is based on an operational plan, which represents the com- plex control instrument formed by the closely tied plans ...
Tomek, Gustav, Vávrová, Věra
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Corporate marketing potential assessment model in the context of operational, tactical and strategic levels [PDF]
Marketing i Menedžment Innovacij, 2013 The aim of the article. The aim of this research is to develope the mathematic model structure of result-oriented evaluation of corporate marketing potential in the context of management potential levels (operational, tactical and strategic) that takes ...
L.V. Potrashkova
doaj
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Fuzzy bi-objective optimization model for multi-echelon distribution network
Ratio Mathematica, 2014 It is important for modern businesses to search the ways for continuous improvement in performance of their supply chains. The effective coordination and integrated decision making across the supply chain enhances the performance among its various ...
Kanika Gandhi, P.C. Jha
doaj