Results 61 to 70 of about 119,125 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Haar Wavelet Based Implementation Method of the Non–integer Order Differentiation and its Application to Signal Enhancement

Measurement Science Review, 2015
Non–integer order differentiation is changing application of traditional differentiation because it can achieve a continuous interpolation of the integer order differentiation. However, implementation of the non–integer order differentiation is much more
Li Yuanlu, Pan Chang, Meng Xiao, Ding Yaqing, Chen Haixiu   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Matrix Regular Operator Spaces

Journal of Functional Analysis, 1998
A norm on an ordered real Banach space \(E\) is called regular (or Riesz norm) if \(-x\leq y\leq x\) implies \(\| y\|\leq\| x\|\), and \(\| y\|< 1\) implies the existence of \(x\in E\) with \(\| x\|< 1\) and \(-x\leq y\leq x\). This concept is generalized to matrix ordered complex operator spaces [as introduced by \textit{M.-D. Choi} and \textit{E.
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A novel Jacobi operational matrix for numerical solution of multi-term variable-order fractional differential equations

Journal of Taibah University for Science, 2020
In this article, we introduce a numerical technique for solving a class of multi-term variable-order fractional differential equation. The method depends on establishing a shifted Jacobi operational matrix (SJOM) of fractional variable-order derivatives.
A. A. El-Sayed, D. Baleanu, P. Agarwal
doaj   +1 more source

On the bands of the Schrödinger operator with a matrix potential

Mathematische Nachrichten, 2023
AbstractIn this article, we consider the one‐dimensional Schrödinger operator with a Hermitian periodic matrix potential Q. We investigate the bands and gaps of the spectrum and prove that most of the positive real axis is overlapped by m bands. Moreover, we find a condition on the potential Q for which the number of gaps in the spectrum of is ...
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source