Results 111 to 120 of about 238,611 (313)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Structural Health Monitoring under Nonlinear Environmental or Operational Influences
Shock and Vibration, 2014 Vibration-based structural health monitoring is based on detecting changes in the dynamic characteristics of the structure. It is well known that environmental or operational variations can also have an influence on the vibration properties.
Jyrki Kullaa
doaj +1 more source
Operational Risk Management using a Fuzzy Logic Inference System [PDF]
Operational Risk (OR) results from endogenous and exogenous risk factors, as diverse and complex to assess as human resources and technology, which may not be properly measured using traditional quantitative approaches.
Carlos León, Alejandro Reveiz
core
On Model- and Data-based Approaches to Structural Health Monitoring [PDF]
, 2010 Structural Heath Monitoring (SHM) is the term applied to the process of periodically monitoring the state of a structural system with the aim of diagnosing damage in the structure.
Barthorpe, Robert James
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Remote SensingMonitoring excited hydroxyl (OH*) airglow is broadly used for characterizing the state and dynamics of the terrestrial atmosphere. Recently, the existence of excited hydroxyl was confirmed using satellite observations in the Martian atmosphere.
Dmitry S. Shaposhnikov +4 more
doaj +1 more source
Operational Monitoring of Trace Gases over the Mediterranean Sea
Advances in Meteorology, 2015 This paper describes the operational implementation of the processor φ-IASI over the Mediterranean sea. The φ-IASI model implements two physically based inversion algorithms for the sequential retrieval of (a) the thermodynamic state of the atmosphere ...
Giuseppe Grieco +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source