Results 181 to 190 of about 247,114 (294)

The effect of supply chain risks management practices on operational performance of pharmaceutical manufacturing companies in Addis Ababa, Ethiopia: Analytical cross-sectional study. [PDF]

PLoS One
Mechal D, Boche B.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The relationship between heterogeneous institutional investors and operational performance: Evidence from mergers and acquisitions. [PDF]

Heliyon
Park YS, Na J.
europepmc   +1 more source

The Mediating Role of Operational Efficiency on the Relationship Between Inventory Management and Financial Management Practices and Financial Performance of Convenience Stores

Joseph Christian E. Suan, Mariel Gwyneth P. Lazarte, Apreal Mae R. Manalansan, Eunice M. Rivera, John Cedric C. Tamayo, Bryan DC. Gabriel, Jomar V. Villena, Francis Allan C. Bernales   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The effect of Ashtanga-Vinyasa Yoga method on air force pilots' operational performance. [PDF]

Front Public Health
Santos S, Melo F, Fernandes O, Parraca JA.   +3 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Leading Through Noise: Operating Room Noise Challenges for Staff and Leadership Techniques to Ensure Optimal Operational Performance. [PDF]

Cureus
Louis M, Grabill N, Strom P, Gibson B.
europepmc   +1 more source

Supply chain management practices and operational performance of fair price shops in India: an empirical study

, 2018
Anil Kumar, Gyaneshwar Singh Kushwaha
openalex   +1 more source

Pool boiling heat transfer: Thermal performance for alternating and extended operational conditions

Tolga Emir, Mete Budaklı, Mehmet Arık
openalex   +2 more sources