Results 161 to 170 of about 1,864,391 (308)

Leveraging probe data to model speeding on urban limited access highway segments: Examining the impact of operational performance, roadway characteristics, and COVID-19 pandemic. [PDF]

Accid Anal Prev, 2023
Marshall E, Shirazi M, Shahlaee A, Ivan JN.   +3 more
europepmc   +1 more source

CBM/PBM Operational Performance

Annual Conference of the PHM Society
Condition-Based Maintenance (CBM) and Predictive-Based Maintenance (PBM) have emerged as pivotal strategies in theaircraft industry, offering the potential to revolutionize maintenance operations. These approaches aim to optimize maintenance schedules, reduce operational costs, increase aircraft and assets availability, and enhance safety by leveraging
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Strengthening operational performance in canine detection teams with double-blind certification testing. [PDF]

Forensic Sci Int Synerg
Quigley-McBride A, Prada-Tiedemann PA, Helfers F.   +2 more
europepmc   +1 more source

Impact of lean service, workplace environment, and social practices on the operational performance of India post service industry. [PDF]

Ann Oper Res, 2022
Vadivel SM, Sequeira AH, Sakkariyas RR, Boobalan K.   +3 more
europepmc   +1 more source

THE ROLE OF BUSINESS INTELLIGENCE IN BUSINESS PERFORMANCE MANAGEMENT [PDF]

Business performance management (BPM) is a key business initiative that enables companies to align strategic and operational objectives with business activities in order to fully manage performance through better informed decision making and action ...
Albescu Felicia, Babeanu Delia, Pugna Irina Bogdana   +2 more
core  

Performing in the operating theater [PDF]

AORN Journal, 2006
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Exploring the operational performance of Indian smes: an integrated PLS-SEM and NCA approach. [PDF]

Sci Rep
Surya A, Kumar R, Trehan R, Yadav A, Qureshi KM, Qureshi MRNM, Mansour M.   +6 more
europepmc   +1 more source