Results 251 to 260 of about 429,215 (310)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Scientific and operational maturity of CE-MS: are we close? [PDF]

Trends Biotechnol
Wang D.
europepmc   +1 more source

The impact of lean methods and tools on the operational performance of manufacturing organisations [PDF]

International Journal of Production Research, 2014
Evidence suggests that lean methods and tools have helped manufacturing organisations to improve their operations and processes. However, the real effect of these methods and tools on contemporary measures of operational performance, i.e.
Vikas Kumar
exaly   +3 more sources

Customer integration and operational performance: The mediating role of information quality [PDF]

Decision Support Systems, 2015
Much supply chain integration literature tends to be biased towards its positive impact on operational performance. However, inconclusive results demand investigation of the mechanisms through which supply chain integration can lead to superior ...
Roberto Chavez, Brian Fynes, Wantao Yu   +2 more
exaly   +3 more sources

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Operating system performance

Communications of the ACM, 1972
An overview of the current and future positions with respect to operating system performance is given. While a great deal of information and a large number of models for subsystems have been developed, gaps still exist in our knowledge. Because of the severe interactions between the various subsystems of an operating system, an overall model of the ...
openaire   +1 more source

Reliable assessment of operative performance

The American Journal of Surgery, 2016
There is no consensus regarding the number of intraoperative assessments required to reliably measure trainee performance. This study used generalizability theory (GT) to describe factors contributing to score variance and to estimate the number of assessments needed to achieve high standards of reliability.While performing laparoscopic procedures ...
Elif Bilgic, Yusuke Watanabe, Katherine McKendy, Amani Munshi, Yoichi M. Ito, Gerald M. Fried, Liane S. Feldman, Melina C. Vassiliou   +7 more
openaire   +2 more sources

Performing Mathematical Operations with Metamaterials

Science, 2014
Computational Metamaterials Optical signal processing of light waves can represent certain mathematical functions and perform computational tasks on signals or images in an analog fashion. However, the complex systems of lenses and filters required are bulky.
Alexandre, Silva, Francesco, Monticone, Giuseppe, Castaldi, Vincenzo, Galdi, Andrea, Alù, Nader, Engheta   +5 more
openaire   +2 more sources

CCTV Operator Performance Benchmarking

2012 IEEE International Carnahan Conference on Security Technology (ICCST), 2012
A range of automated video analytics systems (VAS) is increasingly being used to improve efficiency and effectiveness within CCTV control rooms. Their role is to manage the large volumes of surveillance data that are constantly generated and to sift the data in real time to detect incidents or activities of specific interest.
S. Rankin, N. Cohen, K. MacLennan-Brown, K. Sage   +3 more
openaire   +1 more source