Results 81 to 90 of about 429,215 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of a combat aircraft operational and cost-effectiveness design methodology [PDF]

open access: yes, 2005
This study set out to develop an aircraft design methodology, which gives com- bat aircraft more operational and cost-effectiveness by considering these factors early in the design process.
Nilubol, Otsin
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Understanding the impact of strategic alignment on the operational performance of post implemented technological innovations [PDF]

open access: yes, 2010
Purpose – The purpose of this paper is to examine the role of three strategies - organisational, business\ud and information system – in post implementation of technological innovations.
Vemuri, Ram   +4 more
core  

Engineering management : operational design co-ordination [PDF]

open access: yes, 2004
Effective engineering management is acknowledged as being fundamental to the successful operation of organizations. While traditional and contemporary approaches to operational engineering management are of great significance, there remains a need to ...
Whitfield, Ian   +8 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The relationship between halal food management system critical constructs implementation, operational performance and product quality [PDF]

open access: yes, 2020
Given the limited studies on Halal food management system, this study seeks to assess the relationship between the implementation of Halal food management system critical constructs, operational performance and product quality.
Ab. Rahman, Rozanah   +7 more
core   +1 more source

Analysis of the Operational Performance of International Aviation Institutions with the EIFTOPSIS Method

open access: yesVerimlilik Dergisi
Purpose: The main goal of this study is to rank the operational performance variables used in aviation according to their importance levels and to measure the operational performance of international aviation institutions.
Mustafa Özdemir
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

THE ROLE OF BUSINESS INTELLIGENCE IN BUSINESS PERFORMANCE MANAGEMENT [PDF]

open access: yes
Business performance management (BPM) is a key business initiative that enables companies to align strategic and operational objectives with business activities in order to fully manage performance through better informed decision making and action ...
Albescu Felicia   +2 more
core  

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