Results 171 to 180 of about 70,967 (306)

The stochastic elementary formula method and approximate travelling waves for semi-linear reaction diffusion equations [PDF]

In this thesis we consider approximate travelling wave solutions for stochastic and generalised KPP equations and systems by using the stochastic elementary formula method of Elworthy and Truman.
Zhao, Huaizhong
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Landmark-based morphometrics with fewer landmarks: Some examples for medical entomology. [PDF]

PLoS Negl Trop Dis
Dujardin JP, Sriwichai P, Samung Y, Ruangsittichai J, Sumruayphol S, Dujardin S.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The interaction between the RNA aptamer Dap1 and DasR mirrors DNA operator site recognition in GntR repressors. [PDF]

Nucleic Acids Res
Makarova MO, Hartmann J, Maurer LM, Schweden J, Vockenhuber MP, Weiler S, Egerer-Sieber C, Stiebritz MT, Suess B, Muller YA.   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Valuing conservation and natural wealth: The blue economy of manta ray watching in the Maldives. [PDF]

PLoS One
Moloney HM, Rojas MIG, Rothe N, Armstrong AO, Ballard K, Barraud F, Hamdan F, Richardson AJ, Riyad EM, Sawers TJ, Townsend KA, Stevens GMW.   +11 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

On the well-posedness of some model arising in the mathematical biology [PDF]

In the article we establish the global well-posedness in W^{1, 2, 2}(R\times R^{+}) of the integro-differential equation in the case of the anomalous diffusion when the one dimensional negative Laplace operator is raised to a fractional power in the ...
Efendiev, Messoud, Vougalter, Vitali
core   +1 more source