Results 201 to 210 of about 2,346,209 (353)

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, Volume 15, Issue 5, Page 699-713, May 2025.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Understanding zoonotic disease spread with a fractional order epidemic model. [PDF]

Sci Rep
Althubyani M, Adam HDS, Alalyani A, Taha NE, Taha KO, Alharbi RA, Saber S.   +6 more
europepmc   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, Volume 15, Issue 5, Page 763-772, May 2025.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

HindwingLib: A library of leaf beetle hindwings generated by Stable Diffusion and ControlNet. [PDF]

Sci Data
Yang Y, Li W, Liu R, Wu C, Ren J, Shi Y, Ge S.   +6 more
europepmc   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Metabolite-Responsive Control of Transcription by Phase Separation-Based Synthetic Organelles. [PDF]

ACS Synth Biol
Jerez-Longres C, Weber W.
europepmc   +1 more source

Usefulness of molecular biology tools in the operation and control of the anaerobic digestion process

, 2018
International ...
openaire   +3 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, Volume 15, Issue 5, Page 822-835, May 2025.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Advancing nuclear transfer cloning in zebrafish (Danio rerio) into a translational pathway using interdisciplinary tools. [PDF]

PLoS One
Bodenstein S, Poulos W, Jimenez F, Stout M, Liu Y, Varga ZM, Cibelli J, Tiersch TR.   +7 more
europepmc   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source