Results 101 to 110 of about 458,023 (296)

Commentary Euthanasia Methods in Field Settings for Wildlife Damage Management

open access: yesHuman-Wildlife Interactions, 2017
Timothy J. Julien   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Safety Work as a Factor in Reducing the Number of Injuries of Tractor Operators

open access: yesTehnički Glasnik
Modern agricultural production requires the use of agricultural machinery. Among all agricultural machines, the tractor is one of the most frequently used agricultural machines.
Tomislav Jurić   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Wasserstein-Based Evolutionary Operators for Optimizing Sets of Points: Application to Wind-Farm Layout Design

open access: yesApplied Sciences
This paper introduces an evolutionary algorithm for objective functions defined over clouds of points of varying sizes. Such design variables are modeled as uniform discrete measures with finite support and the crossover and mutation operators of the ...
Babacar Sow   +4 more
doaj   +1 more source

WORK PRECARIOUSNESS: ERGONOMIC RISKS TO OPERATORS OF MACHINES ADAPTED FOR FOREST HARVESTING [PDF]

open access: gold, 2017
Stanley Schettino   +3 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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