Results 111 to 120 of about 147,401 (287)

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Diverse Uses of Lantibiotics: Exploring New Approaches to Combat Antibiotic Resistance

Medicine Advances, EarlyView.
This review illustrates lantibiotics as an alternative therapeutic approach to combat antibiotic resistance, highlighting their diverse sources, including plants, insects, animals, and microorganisms. It further emphasizes their broad therapeutic potential, including antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities (GA ...
Gopalarethinam Janani, Shangavy Pandiarajan, Kunal Biswas, Manickam Rajkumar, Agnishwar Girigoswami, Koyeli Girigoswami   +5 more
wiley   +1 more source

Identification of the Integration/Excision Module and Regulatory Elements Involved in the Mobility of IME8, an Integrative and Mobilizable Element From Mosquitocidal Lysinibacillus sphaericus

Microbial Biotechnology
Lysinibacillus sphaericus, a bacterium successfully used in the control of mosquitoes, bears its insecticidal traits in GI8, a recently identified mosquitocidal genomic island.
Yifeng Hu, Ying Yang, Xiaomin Hu, Jacques Mahillon, Zubin Chen, Han Xia   +5 more
doaj   +1 more source

Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context

Scientific Reports, 2017
BioH is an α/β-hydrolase required for synthesis of the pimelate moiety of biotin in diverse bacteria. The bioH gene is found in different genomic contexts.
Xinyun Cao, Lei Zhu, Zhe Hu, John E. Cronan   +3 more
doaj   +1 more source

The construction of a genome‐wide transposon library of Glaesserella parasuis and its use to identify genes essential for in vitro and in vivo survival

mLife, EarlyView.
Abstract Glaesserella parasuis is an important porcine pathogen that commonly colonizes the upper respiratory tract of pigs and is the etiological agent of Glässer's disease, causing substantial economic losses in the global swine industry. This study aimed to identify genes essential for both in vitro growth and in vivo pathogenicity of G.
Xiaowei Gong, Yuqian Shi, Liuqing He, Qingpo Cui, Guanzheng Zhao, Shuo Xu, Luyu Ying, Qin Yang, Xiaoxia Qin, Tong Sun, Xiaotong Jiang, Juanjuan Wang, Zhangqi Shen, Mengjiao Fu   +13 more
wiley   +1 more source

Predicting The Operon Structure Of Bacillus Subtilis Using Operon Length, Intergeene Distance, and Gene Expression Information

, 2004
Introduction In prokaryotes, open reading frames (ORFs) belonging to the same operon are transcribed together into a single mRNA molecule. To understand gene regulation in prokaryotic organisms, as a first step it is important to determine the operon ...
S. Imoto, N. Ogasawara, S. Miyano, M. J. L. De Hoon, K. Kobayashi   +4 more
core  

DnaK1‐mediated regulation of phototactic motility in Synechococcus elongatus UTEX 3055

mLife, EarlyView.
Abstract Cyanobacterial phototaxis relies on type IV pili (T4P); yet, how light signals are transmitted to the T4P motor remains unresolved. Here, we identify the molecular chaperone DnaK1 as an important regulator of phototactic motility in Synechococcus elongatus UTEX 3055.
Shang‐Yu Li, Qing‐Xue Sun, Dan‐Qing Huang, Tao Xie, Yan Yu, Chenliu He, Cesar A. Valades‐Cruz, Xiaoli Zeng, Yiling Yang, Cheng‐Cai Zhang   +9 more
wiley   +1 more source

Clarification and reprogramming of glucose and xylose metabolism in Sphingomonas sanxanigenens for efficient sanxan biosynthesis

mLife, EarlyView.
Abstract Currently, the production of high‐value chemicals from natural lignocellulose is of great significance for a circular economy. In this study, a robust platform was developed based on Sphingomonas sanxanigenens NXdP, which co‐utilizes glucose and xylose to synthesize polysaccharide sanxan, for efficient bioconversion of lignocellulose‐derived ...
Yue Ming, Zhuangzhuang Shi, Yiting Lin, Jue Li, Weilong Wang, Wei Sha, Guoqiang Li, Mengmeng Wu, Ting Ma   +8 more
wiley   +1 more source

Models for Annotation Count versus Operon Length.

, 2013
Models for Annotation Count versus Operon Length.
Gregory Vey (144622)
core   +1 more source