Results 181 to 190 of about 147,401 (287)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, Volume 600, Issue 19, Page 2947-2960, October 2026.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Algorithm and Software to Type Stx Operons Accurately from Assembled Genomic Sequence. [PDF]

Microorganisms
Prasad AB, Abromaitis S, Brover V, Feldgarden M, Joensen KG, Kapsak CJ, Lindsey RL, Li L, Michelacci V, Schjørring S, Scheutz F, Klimke W.   +11 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Identification and characterization of the hydratase ThnL preparing for the second-ring cleavage in anaerobic naphthalene degradation. [PDF]

Appl Environ Microbiol
Kong Y, Wang Q, Samak NA, Weyrauch P, Meckenstock RU.   +4 more
europepmc   +1 more source

Bacterial Diseases in Farmed Nile Tilapia (Oreochromis niloticus): A Review of Pathogenesis, Immune Responses and Recent Advances in Diagnostics and Management

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
Pathogenesis of bacterial diseases in Nile tilapia and anti‐bacterial mechanisms. ABSTRACT Nile tilapia (Oreochromis niloticus) is among the most widely farmed fish globally that plays a major role in ensuring food security in many low‐ and middle‐income countries.
Catherine Agoe, John Walakira, Gerald Kwikiriza, Nasser Kasozi, Ivan Abaho, Manuel Curto, Paul Meulenbroek, Harald Meimberg, Peter Akoll   +8 more
wiley   +1 more source

Computational Identification of Novel Transcriptional Regulators and Functional Gene Clusters in <i>Lactococcus lactis</i> Using Integrated Bioinformatics Approaches. [PDF]

Microorganisms
Wolf E, Sokolova T, Akberdin I, Sazonov A.   +3 more
europepmc   +1 more source

Harnessing Large Language Models to Advance Microbiome Research: From Sequence Analysis to Clinical Applications

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
Large language models are transforming microbiome research by enabling advanced sequence profiling, functional prediction, and association mining across complex datasets. They automate microbial classification and disease‐state recognition, improving cross‐study integration and clinical diagnostics.
Jieqi Xing, He Wang, Yangyang Sun, Xiaoquan Su, Shunyao Wu   +4 more
wiley   +1 more source

Identification of a Plasmid-Mediated Tellurite-Resistance Gene Operon Conferring High-Level Tellurite Resistance in Escherichia Albertii. [PDF]

Microbiol Immunol
Wakabayashi Y, Nishijima S, Yamaguchi T, Seto K, Kawai T.   +4 more
europepmc   +1 more source

Biological Systems as Physical Data Processors: Evolution as a Case of Embodied Computing

BioEssays, Volume 48, Issue 10, October 2026.
Embodied biological computing is process through which biological systems gravitate toward attractors in a solution space through a thermodynamically favored process of information capture. Applications in biotechnology, in particular metabolic engineering are numerous.
Víctor de Lorenzo
wiley   +1 more source

Influence of iron uptake systems on cefiderocol activity in <i>Escherichia coli</i>: At the crossroads of antibiotic resistance and virulence. [PDF]

Antimicrob Agents Chemother
Mallecot E, Berti V, Petitjean M, Meyer J, Gueye S, Morel-Journel T, Timsit S, Clermont O, Poirel L, Denamur E, Royer G, Armand-Lefevre L.   +11 more
europepmc   +1 more source