Results 91 to 100 of about 118,304 (234)

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, EarlyView.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Associations between microbial dysbiosis and malignancies of the pancreatobiliary system have been described in recent studies. As a result of the limited number of studies that have been done specifically on the malignancies of the biliary tract, information regarding oral, biliary and tumour‐related microbial alterations was ...
Esperouz Fariba, Villani Rosanna, Ciavarella Domenico, Serviddio Gaetano, Lorusso Mauro, Lo Russo Lucio   +5 more
wiley   +1 more source

Effects of Algae β‐Glucan Supplementation on the Performance and Intestinal Immune System of Healthy Weaned Piglets

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT While β‐glucans from plants and yeasts have been extensively studied in weaned piglets, studies examining algae β‐glucans are scarce. Thus, the present study aimed to examine the effects of feeding algae β‐glucan in weaned piglets. Male, 21‐day‐old, weaned crossbred piglets were allotted to three experimental groups, which were fed either an ...
Johanna O. Buckenberger, Felizitas Gutöhrlein, Manfred Henrich, Erika Most, Rose Whelan, John K. Htoo, Robert Ringseis, Klaus Eder   +7 more
wiley   +1 more source

Comprehensive revision of Mallomonas sect. Peroneides stat. nov. (Chrysophyceae) integrating morphology and multigene phylogeny

Journal of Phycology, EarlyView.
Abstract Mallomonas is among the most diverse genera of Chrysophyceae, yet many of its lineages remain taxonomically unresolved due to limited molecular sampling. Mallomonas series Peronoides, historically limited to four species, has posed persistent taxonomic difficulties, most notably the long‐standing and problematic reliance on a rare ...
Petr Knotek, Iva Jadrná, Martin Pusztai, Pavel Škaloud   +3 more
wiley   +1 more source

rRNA operon improves species-level classification of bacteria and microbial community analysis compared to 16S rRNA

Microbiology Spectrum
Precise identification of species is fundamental in microbial genomics and is crucial for understanding the microbial communities. While the 16S rRNA gene, particularly its V3-V4 regions, has been extensively employed for microbial identification ...
Sohyoung Won, Seoae Cho, Heebal Kim
doaj   +1 more source

Ariadnema polymorpha gen. et sp. nov. (Scytonemataceae, Cyanobacteria): A new heterocytous cyanobacterium with true and false branching from ruins in the Brazilian Atlantic Forest

Journal of Phycology, EarlyView.
Abstract A novel heterocytous Cyanobacterium, Ariadnema polymorpha gen. et sp. nov., was observed in the northern Brazilian Atlantic Forest (BAF), a globally significant biodiversity hotspot that has microbiome diversity yet to be explored. Isolated from ancient sugarcane mill ruins within the BAF, the new genus (strain CCAPE130) exhibits a unique ...
Jefferson Vitor Melo Cabral, Haywood Dail Laughinghouse IV, Jonatas Mota Paulino, Watson Arantes Gama   +3 more
wiley   +1 more source

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

FucR Functions as a Transcriptional Regulator for L-Fucose Utilization in Campylobacter jejuni

Microorganisms
Campylobacter jejuni is an enteric pathogen and a major cause of foodborne illness worldwide. It has been shown that C. jejuni primarily utilizes amino acids as its preferred energy source, but its ability to utilize L-fucose can grant a competitive ...
Wayne T. Muraoka, Nicholas Lizer, Peng Liu, Zhangqi Shen, Qingqing Xia, Muslum Ilgu, Qijing Zhang   +6 more
doaj   +1 more source