Engineered Bacterial Membranes as Next‐Generation Platforms for Cancer Immunotherapy
Engineered bacterial membrane platforms, including outer membrane vesicles, bacterial ghosts, genetically engineered membranes, and hybrid bacterial–tumor membranes, integrate tumor antigen presentation with intrinsic immune stimulation. These platforms promote dendritic‐cell activation, T‐cell priming, pyroptosis, and synergistic responses with ...
Hafiza Aasia Malik +4 more
wiley +1 more source
Analysis of the <i>Salmonella enterica</i> serovar Typhimurium Chitobiose ( <i>chb</i> ) Operon. [PDF]
Hobson K, Higgins M.
europepmc +1 more source
Anaerobic biodegradation of benzene by sulphate‐reducing strain BzS1 was studied by combining genomics, differential proteomics and targeted metabolite analyses. Strain BzS1 has an exceptionally streamlined metabolism. A highly abundant heterotrimeric flavoprotein may add benzene to either enolpyruvate or glutaconyl‐CoA followed by channelling into the
Florin Musat +11 more
wiley +1 more source
A plasmid-encoded detoxification system contributing to the survival of <i>Klebsiella oxytoca</i> complex bacteria in the presence of the isothiazolinone biocide MIT/CMIT. [PDF]
Hauf S +3 more
europepmc +1 more source
Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley +1 more source
Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon. [PDF]
Wang B +8 more
europepmc +1 more source
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li +4 more
wiley +1 more source
In Situ Bacterioplankton Growth Partitioning by High‐Resolution Metatranscriptomics
Bacterial growth and primary production are key ecological indicators, yet often measured in bulk. Using metatranscriptomics, the authors identify FtsZ expression to track dividing cells (A, B). Phylogenetic placement of transcripts (C–E) enables linking growth activity to specific taxa (E, F), potentially bridging bulk measurements with fine‐scale ...
J. Cesar Ignacio‐Espinoza +5 more
wiley +1 more source
Harnessing the thermotolerant methylotroph Bacillus methanolicus for methanol-based synthetic L-proline production. [PDF]
Frank C +6 more
europepmc +1 more source
Environmental reservoirs in Bangladeshi hospitals harbor phylogenetically diverse, multidrug‐resistant Pseudomonas aeruginosa with extensive biofilm‐forming capacity and class 1 integron‐associated resistance genes. These findings highlight hospital environments as persistent sources of antimicrobial resistance dissemination and underscore the need for
S. M. Kador +9 more
wiley +1 more source

