Results 31 to 40 of about 2,264 (158)

Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells

open access: yesPharmacological Research - Modern Chinese Medicine, 2022
Ophiopogonin B (OP-B) as a bioactive component of Radix Ophiopogon Japonicus has been reported to induce various kinds of cell death of non-small cell lung cancer (NSCLC) cells, while the underline mechanism is unknown.
Zhihui Li   +11 more
doaj   +1 more source

Prevention of Atopic Dermatitis in High‐Risk Infants: A Review of the Role of Lipid‐Based Barrier Repair Therapy

open access: yesPediatric Dermatology, EarlyView.
ABSTRACT Background/Objective Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid‐based therapies to prevent AD and ...
Chon‐Wai Jeremy Chan   +1 more
wiley   +1 more source

(E)-3-(4-Hydroxy-3-methoxybenzylidene)-4-(4-hydroxyphenyl)pyrrolidin-2-one

open access: yesActa Crystallographica Section E, 2008
The title compound, C18H17NO4, was isolated from an ethanol extract of Ophiopogon japonicus. The dihedral angle between the 4-hydroxy-3-methoxyphenyl ring and the pyrrolidine ring is 17.4 (1)°.
Bo-Yang Yu   +3 more
doaj   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

open access: yesAdvanced Science, Volume 13, Issue 8, 9 February 2026.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu   +15 more
wiley   +1 more source

Effects of polysaccharide from Ophiopogon japonicus on immune response to Newcastle disease vaccine in chicken

open access: yesPesquisa Veterinária Brasileira
: In order to investigate the immune enhancement effects of Ophiopogon japonicus polysaccharide Ophiopogon japonicus (OJPS) on Newcastle disease (ND) live vaccine, chickens vaccinated against ND live vaccine was orally administered with the OJPS at high,
Xu Song   +9 more
doaj   +1 more source

Effects of herbal medicine components on the physical properties of trial denture adhesives

open access: yesDental Journal, 2017
Background: Denture adhesive is widely used in elderly people who wear complete dentures. Chinese herbal medicine has long been used for the treatment of oral disease.
Kenichiro Nakai   +4 more
doaj   +1 more source

Evaluation of the Effects of Paclobutrazol and Cultivation Years on Saponins in Ophiopogon japonicus Using UPLC-ELSD

open access: yesInternational Journal of Analytical Chemistry, 2020
Nowadays, there is a growing concern about the quality of herbs used in traditional Chinese medicine. In this study, we evaluated the impacts of paclobutrazol and cultivation period on steroid saponins in Ophiopogon japonicus.
Peng Sun, Juhua Tong, Xianen Li
doaj   +1 more source

Structural Characterization and Antioxidant Activity of Polysaccharides From Indigo Naturalis Ophiopogon japonicus: Effects of Processing and Extraction Methods

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Indigo naturalis processing significantly increased polysaccharide and uronic acid content, altered monosaccharide composition, and introduced high‐molecular‐weight fractions. Structural changes enhanced DPPH and superoxide anion scavenging activities, especially in reflux‐extracted processed samples (W‐IP, IC50 = 3.19 mg/mL).
Yi Zhao   +9 more
wiley   +1 more source

Extraction, characterization and anti-oxidant activity of polysaccharide from red Panax ginseng and Ophiopogon japonicus waste

open access: yesFrontiers in Nutrition, 2023
Red ginseng and Ophiopogon japonicus are both traditional Chinese medicines. They have also been used as food in China for thousands of years. These two herbs were frequently used in many traditional Chinese patent medicines.
Jia Kang   +5 more
doaj   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

open access: yesAdvanced Science, Volume 12, Issue 47, December 18, 2025.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding   +15 more
wiley   +1 more source

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