Results 101 to 110 of about 27,110 (219)

IL‐17A Promotes NETs Formation via the PKCζ–ERK–ROS–PAD4 Pathway in a Mouse Model of Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Chang Liu, Qi Chen, Weijia Chen, Xinyue Han, Xiaowen Qiao, Jun Guo, Wei Su, Qingqing Dai   +7 more
wiley   +1 more source

Overview of Diagnostic Ultrasound Safety

Journal of Ultrasound in Medicine, Volume 45, Issue 3, Page 487-496, March 2026.
Ultrasound is widely regarded as a safe imaging modality; however, emerging ultrasound‐based techniques—such as shear wave elastography and contrast‐enhanced ultrasound—operate with varying acoustic output parameters that may approach or exceed traditional diagnostic limits. As these technologies are increasingly integrated into human research studies,
Saubhagya Srivastava, Baihui Yu, David Giraud, Manjiri Dighe, Manish Dhyani, Richard G. Barr   +5 more
wiley   +1 more source

Retinal Capillary Density Reduction Contributes to Dysthyroid Optic Neuropathy via an L‐Arginine‐NO Pathway: A Metabonomics and Clinical Trial Study

MedComm, Volume 7, Issue 3, March 2026.
Oxidative stress induces endothelial nitric oxide synthase (eNOS) uncoupling and L‐arginine depletion, reducing nitric oxide (NO) bioavailability in vascular endothelium and contributing to decreased retinal capillary density (RCD) in dysthyroid optic neuropathy (DON).
Yunhai Tu, Congcong Yan, Lu Chen, Weijie Liu, Xiaozhou Hu, Mengyuan Gao, Wei Rao, Jiayi Zhang, Junye Zhu, Hui Wu, Kang Zhang, Meng Zhou, Wencan Wu   +12 more
wiley   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Doppler ultrasound-based evaluation of hemodynamic changes in the ophthalmic artery and central retinal artery in patients with type 1 diabetes mellitus without retinopathy and with mild non-proliferative retinopathy

Journal of Ultrasonography
Determination of blood flow parameters in the ophthalmic artery and central retinal artery using Doppler ultrasound in patients with type 1 diabetes mellitus without fundus signs of diabetic retinopathy and with mild non-proliferative retinopathy.
Pauk-Domańska Magdalena, Wilczewska Agnieszka, Jaguś Dominika, Kaczyński Bartosz, Jakubowski Wiesław   +4 more
doaj   +1 more source

Cerebral in situ ischemic postconditioning: From bench to bedside and beyond

Neuroprotection, Volume 4, Issue 1, Page 48-64, March 2026.
This review explores the translational potential of in situ ischemic postconditioning in acute ischemic stroke. Preclinical and clinical evidence is summarized to highlight its promise as a neuroprotective strategy in the era of endovascular therapy.
Xiao Jiang, Wenbo Zhao, Yongbo Xu, Fanlei Meng, Ming Wei   +4 more
wiley   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 3, March 2026.
ABSTRACT Background Intraoperative hypotension is a common occurrence in patients undergoing anaesthesia, although there is no standardised definition of hypotension. International consensus statements provide some guidelines for the management of intraoperative hypotension, but general clinical practice is unknown.
Emilie S. Bækgaard, Morten Vester‐Andersen, Vera Crone, Morten Hylander Møller, Shun Yamanaka, Rakel Palmarsdottir, Panu Uusalo, Felix Haidl, Madeleine Rådestad, Koene van der Sloot, Andrea Corona, Alexander Johnström, Anders Kehlet Nørskov, Anders P. H. Karlsen, Birgit Isberg Faustad, Christina Borgen Sørensen, Fabian Spies, Hanna Bjarkhamar Krogh, Hayan El‐Hallak, Jacqueline Møller Mistry, Julie Kjerulff Mønnich, Karen Grangård Olesen, Karl P. D. Madsen, Kirsten Lerche Voogd, Laila Mulla Reich, Line Agger Kolstrup, Peter Juhl‐Olsen, Luisa Korsgaard Körner, Martin Ingi Sigurdsson, Mathias Bach Jensen‐Holm, Julie Anna Slavensky, Mette Helene Toft, Michael Leth Jørgensen, Mikkel Andersen, Mikkel Schiødt Heide Jensen, Mojtaba Saei, Morten Hedetoft, Peter Martin Hansen, Rasmus Tofte Hansen, Rune Sarauw Lundsgaard, Sarah Marie Ivan Krarup, Sebastian Wiberg, Torben Laustrup, Guilia Brizzi, Janett Kreutziger, Ifunanya Onyemuchara, Adebisi Adeniji, Thomas Colville, James A. Keitley, Meherunissa Khan, Morven Millar, Iona Lennie, Kieran Kelly, Verity Brooker, Jack Roberts, Gareth Lipton, Jill Keohone, Ryad Chebbout, Oliver Bond, William Milligan, Ciara O'Brien, Edward Wright, Fiona Linton, Charlotte Towell, James Shuttleworth, James Norton, Daniel Butler, Stuart Frankland, Francis Screech, Lucy Charig, Stephanie Walsh, Rhys Davies, Eleanor Jones, Elodia Dalmonte, Matthew Evans, Mette Krag   +75 more
wiley   +1 more source

SD‐OCT‐based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti‐VEGF therapy

Acta Ophthalmologica, Volume 104, Issue 2, Page e152-e164, March 2026.
Abstract Purpose To investigate the role of spectral domain optical coherence tomography (SD‐OCT)‐based biomarkers in predicting treatment response of macular oedema (MO) secondary to retinal vein occlusion (RVO) to anti‐vascular endothelial growth factor (VEGF) therapy.
Ken K. Tsang, Vivian W. K. Hui, Christopher M. K. Pang, Ziqi Tang, Dawei Yang, Truong X. Nguyen, Shaheeda Mohamed, Timothy Y. Y. Lai, Carol Y. Cheung, Simon K. H. Szeto   +9 more
wiley   +1 more source

Use of Transcorneal Iris Photocoagulation to Facilitate Sector Iridectomy of Pigmented Iridal Tumors: A Case Series of Five Eyes (Three Dogs and One Cat)—Clinical Findings, Surgical Technique, Complications, and Outcome

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Objective To describe the use of transcorneal iris photocoagulation (TCIP) to improve intraocular visualization of intended incision lines, reduce hemorrhage, and facilitate excision of pigmented iridal tumors in four canine eyes and one feline eye.
A. K. Shukla, P. Grest, N. Holz, A. Rampazzo, S. A. Pot   +4 more
wiley   +1 more source