Results 131 to 140 of about 36,524 (294)

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Impact of mono‐ or multitherapy on ocular surface health and quality of life after 5 years of follow‐up in the Glaucoma Intensive Treatment Study (GITS)

Acta Ophthalmologica, EarlyView.
Abstract Aim To evaluate the impact of initial mono‐ versus multitherapy on the ocular surface and related quality of life after 5 years follow‐up in the Glaucoma Intensive Treatment Study (GITS). Method The study included patients with primary open‐angle glaucoma and pseudoexfoliation glaucoma who completed 5‐year follow‐up in GITS.
Gauti Jóhannesson, Christina Lindén, Johan Aspberg, Sabina Andersson‐Geimer, Anders Heijl, Boel Bengtsson, Dorothea Peters   +6 more
wiley   +1 more source

Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system

Indian Journal of Ophthalmology, 2010
Background: Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids on stimulation, such as pH, temperature and ionic change.
Singh Vinod, Bushetti S, Appala Raju, Shareef Adil, Imam Syed, Singh Mamta   +5 more
doaj  

Nanoemulsions as Ophthalmic Drug Delivery Systems [PDF]

Turk J Pharm Sci, 2021
Dhahir RK, Al-Nima AM, Al-Bazzaz FY.
europepmc   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment. [PDF]

Sci Adv, 2023
Shen J, Gao H, Chen L, Jiang Y, Li S, Chao Y, Liu N, Wang Y, Wei T, Liu Y, Li J, Chen M, Zhu J, Liang J, Zhou X, Zhang X, Gu P, Chen Q, Liu Z.   +18 more
europepmc   +1 more source

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

Epilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed, Lauren M. Aiani, Eesha Faiz, Emmanuel Adediran, Morris Benveniste, Kevin S. Murnane, Martin D'Souza, Andrew Escayg, Jennifer C. Wong   +8 more
wiley   +1 more source

Progress on contact lens for extended ophthalmic drug delivery

, 2022
Zhao Wang, Qing Lin, Xiaojuan Zhang, Xiaomei Wang, Lingyun Hao   +4 more
openalex   +2 more sources

Matrix Metalloproteinases and Glaucoma Treatment. [PDF]

, 2020
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed, Robinson, Michael R, Stamer, W Daniel, Weinreb, Robert N   +3 more
core  

Healthcare Professionals' Perceptions of Artificial Intelligence in Healthcare—A Systematic Review of Qualitative Studies

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify the experiences and perceptions of healthcare professionals on artificial intelligence in healthcare. Design Systematic literature review of qualitative studies and meta‐aggregation. Data Sources CINAHL, PubMed, Scopus, Medic and ProQuest were systematically searched on December 9, 2024. Results Twenty‐six studies were included
Huotari Sini, Mikkonen Kristina, Jarva Erika, Suonnansalo Petra, Kaikkonen Assi, Lee Jay Jung Jae, Oikarinen Anne   +6 more
wiley   +1 more source