Results 111 to 120 of about 3,065,508 (250)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu +4 more
wiley +1 more source
Solubility Enhancement of Water Insoluble Drug for Ophthalmic Formulation [PDF]
, 2011 Product development of ophthalmic preparations has received considerable attention in the last few years. With the increasing emphasis on their sterility, some of the differences between them and parenteral preparations are becoming less evident.
Kulkarni, Sunisha; Sri Ram College of pharmacy, Banmore, Morena (M.P.)-INDIA +3 more
core +2 more sources
Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs
International Journal of Polymer Science, 2011 Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility
Xiaohong Hu +6 more
doaj +1 more source
, 2020 Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana +7 more
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu +15 more
wiley +1 more source
Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
Nanomaterials, 2019 The bioavailability of ophthalmic therapeutics is reduced because of the presence of physiological barriers whose primary function is to hinder the entry of exogenous agents, therefore also decreasing the bioavailability of locally administered drugs ...
Simona Sapino +7 more
doaj +1 more source
Microneedles for ophthalmic drug delivery: recent developments. [PDF]
Int J Surg, 2023 Chopra H +3 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system
Indian Journal of Ophthalmology, 2010 Background: Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids on stimulation, such as pH, temperature and ionic change.
Singh Vinod +5 more
doaj
Tamarind seed polysaccharide (TSP) uses in ophthalmic drug delivery
Revista de Ciências Farmacêuticas Básica e Aplicada, 2021 At present, ophthalmic drug delivery remains a major challenge, given the eye's prot ective structure and susceptibility to irritation, resulting in poor patient adherence.
Matheus Augusto de Castro +2 more
doaj