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Nanomaterial-based ophthalmic drug delivery
Advanced Drug Delivery Reviews, 2023The low bioavailability and side effects of conventional drugs for eye disease necessitate the development of efficient drug delivery systems. Accompanying the developments of nanofabrication techniques, nanomaterials have been recognized as promising tools to overcome these challenges due to their flexible and programmable properties.
Jinyao Liu
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Cyclodextrins in ophthalmic drug delivery
Advanced Drug Delivery Reviews, 1999Most ocular diseases are treated by topical drug application in the form of aqueous eye drop solutions. Recent studies have shown that cyclodextrins are useful additives in ophthalmic formulations for increasing the aqueous solubility, aqueous stability and bioavailability of ophthalmic drugs, and to decrease drug irritation.
, Loftssona, , Järvinen
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Microparticulates for Ophthalmic Drug Delivery
Journal of Ocular Pharmacology and Therapeutics, 1994Microparticulates are drug-containing small polymeric particles (erodible, non-erodible or ion-exchange resins) that are suspended in a liquid carrier medium. Upon administration of particle suspension in the eye, the particles reside at the delivery site (cul-de-sac, sub conjunctiva or vitreous cavity) and the drug is released from the particles ...
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Colloidal Carriers for Ophthalmic Drug Delivery
Current Drug Targets, 2005To achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors. Most ocular diseases are treated by topical drug application in the form of solution, suspension and ointment ...
Rubiana Mara, Mainardes +6 more
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Ophthalmic drug delivery systems
Drug Development Research, 1984AbstractNew ophthalmic drug delivery systems are curently receiving increased attention, in part because of the expected emergence of new drugs with short biological half‐lives whose usefulness may depend on a more continuous drug supply than eyedrops can provide, but also because of the potential of some delivery systems to reduce the side effects of ...
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Ophthalmic and Otic Drug Delivery
2019This chapter introduces special considerations and formulation techniques for ophthalmic and otic drug delivery. Types of ophthalmic dosage forms are reviewed and placed in clinically relevant context. Commonly used excipients and their functions are also reviewed.
Ashlee D. Brunaugh +2 more
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Ophthalmic Drug Delivery Systems
2003Providing over 2000 references, this book reviews the ophthalmic drug delivery systems currently available or in various stages of research and development, and analyzes the suitability of particular modes of administration for a disease state.
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The ophthalmic rod: A new ophthalmic drug delivery system I
Graefe's Archive for Clinical and Experimental Ophthalmology, 1990The ophthalmic rod (OR) is a new drug delivery system, intended as an alternative to conventional therapy in ophthalmology. The rod is made of a nontoxic plastic. It is dipped into a drug solution which after drying forms a thin homogeneous coating. The OR is then packed and sterilized by gamma radiation. The effects of radiation on the contents of the
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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Development of a Liposomal Gel for Prolonged Ophthalmic Soluble Drug Delivery
ChemistrySelect, 2023Vahid Ramezani
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