Results 81 to 90 of about 3,065,508 (250)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Drug delivery strategies to improve the treatment of corneal disorders

Heliyon
Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases.
Mahsa Fallah Tafti, Zeinab Fayyaz, Hossein Aghamollaei, Khosrow Jadidi, Shahab Faghihi   +4 more
doaj   +1 more source

Mucoadhesive microparticles engineered for ophthalmic drug delivery [PDF]

Journal of Physics and Chemistry of Solids, 2008
Although topical drug delivery is a convenient route of administration to treat various eye diseases, it has serious limitations due to rapid clearance of the formulation from the surface of the eye. In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface.
Young, Bin Choy, Jung-Hwan, Park, Mark R, Prausnitz   +2 more
openaire   +2 more sources

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Drug delivery to eye: Special reference to nanoparticles [PDF]

, 2011
Controlled and sustained delivery of ophthalmic drugs continues to remain a major focus area in the field of pharmaceutical drug delivery with the emergence of new, more potent drugs and biological response modifiers that may also have very short ...
Das, Swarnali; School of Pharmacy and Technology Management, NMIMS University, Mumbai, Maharastra, India, Suresh, Preeti K.; Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chattisgarh, India   +1 more
core  

Eye Drops to smart gels: The future of ocular drug delivery [PDF]

This review paper assesses traditional and modern methods to enhance ocular drug delivery. Various techniques available to administer drugs include topical application, intracameral injections, intravitreal injections, and subconjunctival injections.
Bhaskar , Rajveer, Khade , Shivani, Tikhe , Rohini, Pawar , Arun, Shinde , Sunil, Ola , Monika, Madwe, Vaishnavi   +6 more
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

A Potential Application of a Piezoelectric Atomiser for Ophthalmic Drug Delivery

Applied Bionics and Biomechanics, 2007
A liquid atomiser composed of a piezoelectric transducer and a metal plate with numerous micro-apertures is studied to identify the most influential factors on its atomising performance.
Wei Xia, Hung-Yao Hsu, Lingxue Kong, Allan Evans, Ryan Lee   +4 more
doaj   +1 more source

Hydrogels in ophthalmic drug delivery system - A mini review [PDF]

, 2018
The frequent demand for effective eye therapies is acting as driving force for the development of injectable hydrogels as new medical devices for controlled delivery and filling purposes. The delicate structure and the protective physiological process of
Dhiman Shivani, Dass Rameshwar, Singh Ranjit, Sharma Anjali   +3 more
core   +1 more source