Results 71 to 80 of about 3,065,508 (250)
Advanced Science, EarlyView.TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu +12 more
wiley +1 more source
Advancement and Tribulations in Ocular Drug Delivery [PDF]
, 2012 Development of new drug candidates and novel delivery techniques for treatment of ocular diseases has recently accelerated. The field of ocular drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist for
Sachdev Yadav +3 more
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Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Advanced Science, EarlyView.A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li +9 more
wiley +1 more source
Drug delivery to eye: Special reference to nanoparticles [PDF]
, 2010 Controlled and sustained delivery of ophthalmic drugs continues to remain a major focus area in the field of pharmaceutical drug delivery with the emergence of new, more potent drugs and biological response modifiers that may also have very short ...
Preeti K. Suresh, Swarnali Das
core
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Ocular administration of acetazolamide microsponges in situ gel formulations
Saudi Pharmaceutical Journal, 2018 In the present work, the antiglaucoma drug, acetazolamide, was formulated as microsponges in situ gel for ocular drug delivery aiming an improved therapeutic efficacy and reduction in the systemic side effects of oral acetazolamide. The microsponges were
Manar M. Obiedallah +2 more
doaj +1 more source
Thermoresponsive Hydrogels with Tunable Viscoelasticity for Extended Ocular Drug Delivery
The conformation of charged polymers is heavily dependent on interactions with the surrounding salt ions. By adding calcium ions to hyaluronan-Pluronic F-127 complexes, we prepared colloidal coacervates with decreased viscosity at cold temperatures (G ...
Subrizi, Astrid +8 more
core +1 more source
, 2011 The study was aimed at the evaluation of N-vinyl pyrrolidone (NVP) incorporated polymethacrylic acid-chitosan microparticles for oral drug delivery applications. Poly (methacrylic acid)-chitosan (PMC) and poly(methacrylic acid-vinyl pyrrolidone)-chitosan
core +1 more source
Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources
, 2023 Nanomaterials (NMs) synthesized from natural sources have been attracting greater attention, due to their intrinsic advantages including biocompatibility, stimuli-responsive property, nontoxicity, cost-effectiveness, and non-immunogenic characteristics ...
Mekala Veerapandian +6 more
core +1 more source