Results 251 to 260 of about 36,524 (294)
Some of the next articles are maybe not open access.
Colloidal Carriers for Ophthalmic Drug Delivery
Current Drug Targets, 2005To achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors. Most ocular diseases are treated by topical drug application in the form of solution, suspension and ointment ...
Rubiana Mara, Mainardes +6 more
openaire +2 more sources
Ophthalmic drug delivery systems—Recent advances
Progress in Retinal and Eye Research, 1998Eye-drops are the conventional dosage forms that account for 90% of currently accessible ophthalmic formulations. Despite the excellent acceptance by patients, one of the major problems encountered is rapid precorneal drug loss. To improve ocular drug bioavailability, there is a significant effort directed towards new drug delivery systems for ...
C L, Bourlais +5 more
openaire +2 more sources
Microparticulates for Ophthalmic Drug Delivery
Journal of Ocular Pharmacology and Therapeutics, 1994Microparticulates are drug-containing small polymeric particles (erodible, non-erodible or ion-exchange resins) that are suspended in a liquid carrier medium. Upon administration of particle suspension in the eye, the particles reside at the delivery site (cul-de-sac, sub conjunctiva or vitreous cavity) and the drug is released from the particles ...
openaire +2 more sources
New Ophthalmic Drug Delivery Systems
Drug Development and Industrial Pharmacy, 1995AbstractOne of the ways to optimize ocular drug delivery is to prolonge precorneal drug residence time. This review focusses on recent findings on the formulation effects in ocular drug bioavailability, employing polymers for the preparation of hydrogels, bioadhesive dosage forms, in situ gelling systems and colloidal systems including liposomes and ...
C. A. Le Bourlais +4 more
openaire +1 more source
Ion Exchange Nanoparticles for Ophthalmic Drug Delivery
Bioconjugate Chemistry, 2020We report here on ion-exchange polymeric nanoparticles from a linear copolymer of maleic anhydride methyl vinyl ether esterified with 30% octadecanol. The side chains for the polymer structure were optimized through metadynamics simulations, which revealed the use of octadecanol esters generates ideal free energy surfaces for drug encapsulation and ...
Arijit Basu, Abraham J. Domb
openaire +2 more sources
Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery
Recent Patents on Drug Delivery & Formulation, 2020Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including ...
Srividya, Gorantla +6 more
openaire +2 more sources
Ophthalmic Drug Delivery Systems
2003Providing over 2000 references, this book reviews the ophthalmic drug delivery systems currently available or in various stages of research and development, and analyzes the suitability of particular modes of administration for a disease state.
openaire +1 more source
Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery
Macromolecular Bioscience, 2019AbstractBlindness and vision impairment are major global health problems. Effective ophthalmic drug delivery poses a significant challenge because of protective physiological barriers and various biological clearance mechanisms that result in extremely low ocular bioavailability. Over the past several decades, several safe and effective ophthalmic drug
Deqing Lin +3 more
openaire +2 more sources
Ophthalmic and Otic Drug Delivery
2019This chapter introduces special considerations and formulation techniques for ophthalmic and otic drug delivery. Types of ophthalmic dosage forms are reviewed and placed in clinically relevant context. Commonly used excipients and their functions are also reviewed.
Ashlee D. Brunaugh +2 more
openaire +1 more source
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly