Results 231 to 240 of about 36,131 (273)
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New Ophthalmic Drug Delivery Systems
Drug Development and Industrial Pharmacy, 1995AbstractOne of the ways to optimize ocular drug delivery is to prolonge precorneal drug residence time. This review focusses on recent findings on the formulation effects in ocular drug bioavailability, employing polymers for the preparation of hydrogels, bioadhesive dosage forms, in situ gelling systems and colloidal systems including liposomes and ...
C. A. Le Bourlais +4 more
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Ion Exchange Nanoparticles for Ophthalmic Drug Delivery
Bioconjugate Chemistry, 2020We report here on ion-exchange polymeric nanoparticles from a linear copolymer of maleic anhydride methyl vinyl ether esterified with 30% octadecanol. The side chains for the polymer structure were optimized through metadynamics simulations, which revealed the use of octadecanol esters generates ideal free energy surfaces for drug encapsulation and ...
Arijit Basu, Abraham J. Domb
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Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery
Recent Patents on Drug Delivery & Formulation, 2020Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including ...
Srividya, Gorantla +6 more
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Ophthalmic Drug Delivery Systems
2003Providing over 2000 references, this book reviews the ophthalmic drug delivery systems currently available or in various stages of research and development, and analyzes the suitability of particular modes of administration for a disease state.
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Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery
Macromolecular Bioscience, 2019AbstractBlindness and vision impairment are major global health problems. Effective ophthalmic drug delivery poses a significant challenge because of protective physiological barriers and various biological clearance mechanisms that result in extremely low ocular bioavailability. Over the past several decades, several safe and effective ophthalmic drug
Deqing Lin +3 more
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Ophthalmic and Otic Drug Delivery
2019This chapter introduces special considerations and formulation techniques for ophthalmic and otic drug delivery. Types of ophthalmic dosage forms are reviewed and placed in clinically relevant context. Commonly used excipients and their functions are also reviewed.
Ashlee D. Brunaugh +2 more
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Ophthalmic Drug Delivery: Development and Regulatory Considerations
Clinical Pharmacology & Therapeutics, 2009This review presents an update on the development of ophthalmic drug delivery systems (Table 1), as well as regulatory aspects of product development. This review is based on full papers and published patents as of November 2008.
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Drug Delivery from Ophthalmic Lenses
2020Glaucoma is one of the most common diseases that is characterized by an increase of the IOP that can lead to the damage of the optical nerve. Glaucoma patients are usually treated with eye drops. However, the effectiveness of glaucoma drops is very law because less than 5% of the applied drug reaches the target. In this paper, we discuss mathematically
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DRUG DELIVERY STRATEGIES FOR COMBINATION OPHTHALMIC TREATMENTS
Retina, 2009The most significant obstacle to the combination of drug therapies in age-related macular degeneration (AMD) may be drug delivery. Although the posterior of the eye can be reached by intravitreal injections and implants, AMD is a chronic disease process that is likely to require prolonged or indefinite exposure to antiproliferative agents.
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The ophthalmic rod: A new ophthalmic drug delivery system I
Graefe's Archive for Clinical and Experimental Ophthalmology, 1990The ophthalmic rod (OR) is a new drug delivery system, intended as an alternative to conventional therapy in ophthalmology. The rod is made of a nontoxic plastic. It is dipped into a drug solution which after drying forms a thin homogeneous coating. The OR is then packed and sterilized by gamma radiation. The effects of radiation on the contents of the
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