Results 81 to 90 of about 2,806,264 (293)

Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation. [PDF]

Pharm Res, 2023
Le Merdy M, AlQaraghuli F, Tan ML, Walenga R, Babiskin A, Zhao L, Lukacova V.   +6 more
europepmc   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Microbial contamination and biofilm formation in ophthalmic solutions and ophthalmic instruments at optometry practice [PDF]

Background: Maintaining sterility and preventing microbial contamination are critical in optometry, where multiple surfaces, devices, and solutions contact the patient's eyes, posing an infection risk.
Abdul Rahim, Muhammad Afzam Shah, Abd Karim, Aina Balqis, Ahmad Yusof @ Hanafi, Hanani, Yusof @ Alias, Firdaus, Buari, Noor Halilah, Saad Al Saadoun, Aisyah   +5 more
core  

Randomized, Controlled Study to Evaluate the Safety and Efficacy of Oxygen-Enriched Epithelium-On Corneal Cross-Linking for the Treatment of Keratoconus

Ophthalmology and Therapy
Introduction This phase 3, multicenter, sham procedure/placebo-controlled, double-masked, randomized clinical trial evaluated the safety and efficacy of oxygen-enriched epithelium-on corneal collagen cross-linking (CXL) for the treatment of keratoconus ...
Kenneth A. Beckman, Gregory D. Parkhurst, James H. Lee, Zaina N. Al-Mohtaseb, Michael D. Greenwood, Marco Armijo, Valerie Smith, Erin H. Leone, Angela C. Kothe, Tomas Navratil   +9 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Topical ophthalmic antimicrobials: unfulfilled demands and possibility of new investments in Brazil and in the United States

Brazilian Journal of Pharmaceutical Sciences, 2019
In general, topical ophthalmic drug products, especially those used for treating infections, present low effectiveness because of various reasons, from unfavorable drug physicochemical properties to physiological protective mechanisms of the eye.
Bianca Kollross, Guilherme Martins Gelfuso, Marcilio Cunha-Filho, Tais Gratieri   +3 more
doaj   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

Ophthalmic salines and the acidity question [PDF]

, 1990
What acidity (minimum pH) will most patients tolerate when using ophthalmic salines? After sone decades of trying to answer that question (and many continue to try), it is becoming increasingly evident that the question rather then the answer may be ...
Carney, Leo G., Hill, Richard M., Habenicht, Brenda L.   +2 more
core  

An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival. [PDF]

J Clin Med, 2022
Freiberg JC, Hedengran A, Heegaard S, Petrovski G, Jacobsen J, Cvenkel B, Kolko M.   +6 more
europepmc   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source