Results 71 to 80 of about 2,806,264 (293)
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Analysis of Ophthalmic Surgery Under General Anesthesia at Dokkyo Medical University Koshigaya Hospital [PDF]
, 2014 To analyze ophthalmic surgeries performed under general anesthesia at Dokkyo Medical University KoshigayaHospital. A total of 218 patients( 226 cases) underwent ophthalmic surgery under general anesthesia.Records of ophthalmic surgery patients who ...
Chikuda, Makoto, Muto, Tetsuya
core
Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Advanced Science, EarlyView.A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li +9 more
wiley +1 more source
Commercial eye drops fail to fully meet the therapeutic requirements for infectious ocular diseases. When treating certain infectious ocular diseases where existing ophthalmic preparations are inadequate, extemporaneously prepared eye drops become ...
Ophthalmic Pharmacy Expert Committee of Guangdong Pharmaceutical Association
core +1 more source
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Microbiological assay for the determination of azithromycin in ophthalmic solutions
, 2005 The validation of a simple, sensitive and specific agar diffusion bioassay, applying cylinder-plate method, for the determination of the antibiotic azithromycin in ophthalmic solutions is described.
Salgado, Hérida Regina Nunes +1 more
core +1 more source
Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair
Advanced Science, EarlyView.Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou +14 more
wiley +1 more source
Advanced Science, EarlyView.Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu +12 more
wiley +1 more source
System for ophthalmic dispensing /
, 2007 The ultimate ophthalmic dispensing reference, this book provides a step-by-step system for properly fitting and adjusting eyewear. It covers every aspect of dispensing - from basic terminology to frame selection to eyewear fitting, adjusting, and ...
Borish, Irvin M., Brooks, Clifford W.
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Ophthalmology and Therapy, 2019 Introduction Brimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues ...
Keisuke Shinno +5 more
doaj +1 more source