Results 161 to 170 of about 2,872,365 (306)

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis

Addiction, EarlyView.
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
Erica McAdam, Mohammad Karamouzian, Michael John Milloy, Carmen Verdicchio, Eric C. Sayre, Kanna Hayashi, Thomas Kerr, Kora DeBeck   +7 more
wiley   +1 more source

Prescribed alternative stimulants among people who use unregulated stimulants: Examining the association between maximum dose reached and medication discontinuation in the first 3 years of implementation in British Columbia, Canada

Addiction, EarlyView.
Abstract Background and aims In 2020, British Columbia (BC), Canada, introduced ‘Prescribed Alternatives’ (PA) as an approach to offering regulated substances to people accessing the unregulated supply. This study aimed to estimate and compare prescribing characteristics of dextroamphetamine and methylphenidate stimulant PAs in BC, to estimate ...
Bin Zhao, Kevin Hu, Roshni Desai, Shania Au, Kali‐olt Sedgemore, Vitor Tardelli, Addie Carter, Paxton Bach, Christian Schutz, Amanda Slaunwhite, Alexis Crabtree, Heather Palis   +11 more
wiley   +1 more source

Improving hospital-based opioid substitution therapy (iHOST): protocol for a mixed-methods evaluation [version 2; peer review: 2 approved]

NIHR Open Research
Background Opioid substitution therapy (also known as ‘opioid agonist therapy’ or ‘medication treatment of opioid use disorder’) is associated with improved health and social outcomes for people who use heroin and other illicit opioids.
Marisha Wickremsinhe, Dan Lewer, Adam Burns, Michael Brown, Rosalind Gittins, Niamh Eastwood, Vivian Hope, Adam Holland, Penny Lewthwaite, Aubrey Ko, Adrian Noctor, Ann-Marie Morris, Jenny Scott, Andrew Preston, Sedona Sweeney, Erica Smith, Magdalena Harris, Nerissa Tilouche   +17 more
doaj   +1 more source

Methylenedioxymethamphetamine (MDMA)‐related fatal poisoning in Australia, 2016 to 2025: Trends, characteristics and toxicology

Addiction, EarlyView.
Abstract Aims To determine: (1) Population rates of fatal methylenedioxymethamphetamine (MDMA)‐related poisoning over the period 2016–2023, years with high closure rates in the National Coronial Information System (NDIS); (2) the case characteristics of known cases of fatal MDMA‐related poisoning, 2016–2025; and (3) whether there have been changes in ...
Shane Darke, Johan Duflou, Agata Chrzanowska, Michael Farrell, Julia Lappin, Amy Peacock   +5 more
wiley   +1 more source

“With this you’re not chained down to something”: contrasting experiences of opioid agonist treatment and safer supply program participation among people receiving prescribed safer supply

Harm Reduction Journal
Highlights Participants enrolled in a prescribed safer opioid supply program receive wrap-around care from an interdisciplinary team. Participants contrasted positive experiences of the program with prior negative experiences of opioid agonist therapy ...
Liam Michaud, Adrian Guta, Melissa Perri, Ashley Schaff, Megan Boyle, Kourteney King, Carol Strike, Gillian Kolla   +7 more
doaj   +1 more source

The association between chronic pain and non‐fatal overdose in people who inject drugs: Longitudinal cohort study in Montreal, Canada, 2017 to 2025

Addiction, EarlyView.
Abstract Background and aims The prevalence of chronic pain is elevated among people who inject drugs. Chronic pain may motivate drug use, potentially increasing the risk of non‐fatal overdose. We aimed to estimate the association between chronic pain and non‐fatal overdose in people who inject drugs.
Sarah Larney, Geng Zang, Harika Dasari, M. Gabrielle Pagé, Farzaneh Vakili, Adelina Artenie, Valérie Martel‐Laferrière, Nanor Minoyan, Sasha Udhesister, Julie Bruneau   +9 more
wiley   +1 more source

Chronic pain treatment experiences and barriers among opioid agonist treatment participants who inject drugs: A qualitative study

Addiction, EarlyView.
Abstract Background and aim Co‐occurring chronic pain affects nearly half of people receiving opioid use disorder (OUD) treatment. Although this pain is often severe, it is usually inadequately managed. Stigma and clinical complexity associated with OUD are thought to further restrict access to pain care.
Jie Yang, Shelley Walker, Amy G. McNeilage, Peter Higgs, Louisa Picco, Paul Dietze, Suzanne Nielsen   +6 more
wiley   +1 more source

Safety and Efficacy of Combined Injection of Pure-μ-Opioid Agonist with Tramadol as an Opioid Induction Agent for Opioid-Naïve Cancer Patients

Palliative Medicine Reports
Background: Tramadol is known to provide synergistic analgesia when used in combination with morphine. Objectives: The aims of this study were: (1) to introduce an opioid combination therapy using pure-μ-opioid receptor agonist (OPI) + tramadol ...
Tetsumi Sato, Shigeki Ono, Tetsu Sato, Rei Tanaka, Yoshiko Kamo, Tomomi Suzuki   +5 more
doaj   +1 more source

Variation in 90‐day substance use disorder‐related acute care events across United States opioid treatment programs: A Medicaid claims analysis

Addiction, EarlyView.
Abstract Background and aims Creating and tracking quality measures has improved outcomes in many areas of healthcare; however, quality measures specific to opioid treatment programs (OTPs) have not yet been developed. Based on the success seen in other fields, introducing quality measures in OTPs should help enhance positive outcomes and decrease ...
Barrett Wallace Montgomery, Tami L. Mark, Thanh Lu, William N. Dowd, Dylan DeLisle, Kathryn N. Burke, Daniel H. Barch, Gary A. Zarkin   +7 more
wiley   +1 more source

Probable cychlorphine exposure in a patient with opioid use disorder: A case report

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Cychlorphine is an emerging synthetic opioid with limited clinical data. Methods We describe a patient's reported cychlorphine use and its's clinical effects. Results Thirty‐five years old male with opioid use disorder reported purchasing cychlorphine online.
Manroop Bal, Nimna Mendis, Melissa Bennett, David Kinniburgh, Jeremy Weleff   +4 more
wiley   +1 more source