Results 161 to 170 of about 55,987 (250)

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Adjuvant non-opioid analgesics decrease in-hospital mortality in targeted patients with acute pancreatitis receiving opioids. [PDF]

Eur J Gastroenterol Hepatol
Zeng J, He H, Song Y, Wei W, Han Y, Su X, Lyu W, Zhao J, Han L, Wu Z, Wang Z, Wei K.   +11 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment: A Global Meta-Analysis, 2000-2022. [PDF]

China CDC Wkly
Jiang H, Xing X, Zhu H, Dong T.
europepmc   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Receipt of Smoking Cessation Medications and Smoking Abstinence Among Veterans Prescribed Opioid Analgesics With and Without Cannabis Use. [PDF]

J Gen Intern Med
Nguyen N, Leonard S, Cohen BE, Herbst ED, Hoggatt KJ, Keyhani S.   +5 more
europepmc   +1 more source

Underpowered study design invalidates conclusions of LTAP versus LWI in peritoneal endometriosis surgery

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Ding Li, Song Ye
wiley   +1 more source

Identification, reliability, and validity of drug–drug interaction checkers in chronic diseases: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Drug–drug interactions (DDIs) pose major risks in chronic disease management where polypharmacy is common. Although digital DDI tools are used widely to aid healthcare professionals, tools rely on theoretical interactions. This limitation questions their reliability and validity for clinical relevancy.
Brayden Ng Gibson, Sri Chodapuneedi, Huan Yee Koh, Sugandha Gupta, Danijela Gasevic, Anna Yuanyuan Wang, Catia Marzolini, Saye Khoo, Lorena Romero, Lachlan Dalli, Jack Janetzki, Harvey Jia Wei Koh, Stella Talic   +12 more
wiley   +1 more source