Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery [PDF]
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +4 more sources
In vivo detection of optically-evoked opioid peptide release [PDF]
eLife, 2018 Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo.
Ream Al-Hasani +8 more
doaj +5 more sources
Involvement of the Opioid Peptide Family in Cancer Progression [PDF]
Biomedicines, 2023 Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez +2 more
doaj +2 more sources
Evaluation of [Cys(ATTO 488)8]Dermorphin-NH2 as a novel tool for the study of μ-opioid peptide receptors. [PDF]
PLoS ONE, 2021 The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant problems ...
Despina Giakomidi +9 more
doaj +2 more sources
CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture. [PDF]
PLoS ONE, 2014 Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pain, but molecular mechanisms remain largely enigmatic. In the early phase of inflammation neutrophilic chemokines direct opioid-containing neutrophils in the ...
Ying Wang +5 more
doaj +3 more sources
An opioid-like system regulating feeding behavior in C. elegans [PDF]
eLife, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Mi Cheong Cheong +3 more
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Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells [PDF]
LifeBackground: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice.
Moe Fukunaga +3 more
doaj +2 more sources
A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central
Daniela da Fonseca Pacheco +4 more
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Neuro-physiological characterization of opioid peptide actions on neurohumoral transmission in the mammalian central nervous system [PDF]
, 1986 Mercuri, Nicola +4 more
core +3 more sources
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +14 more sources