Results 1 to 10 of about 4,069 (216)
Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
Peter W. Schiller
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Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael Remesic +2 more
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Non-Opioid Peptides Targeting Opioid Effects [PDF]
International Journal of Molecular Sciences, 2021 Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of ...
Katarzyna Kaczyńska +1 more
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Opioid peptides and metabolic regulation [PDF]
Diabetologia, 1988 La liaison entre opioides et obesite pourrait passer par des anomalies de l'insulino-secretion puisque une augmentation de la sensibilite des cellules B pancreatiques a la beta-endorphine a ete demontree chez les sujets obeses. Une profonde alteration du systeme opioide est presente dans le diabete sans que l'on puisse dire encore si cela represente un
GIUGLIANO, Dario +3 more
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Opioid peptides and the heart [PDF]
Cardiovascular Research, 1999 See article by Millington et al. ([1], pages 107–116) in this issue. In this issue Millington et al. [1] describe the localization of pro-opiomelanocortin (POMC) message and peptide products in adult and neonatal rat heart. These authors are to be commended for delving into the esoteric area of cardiac endocrine function and opioid peptides.
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THE NEUROENDOCRINOLOGY OF OPIOID PEPTIDES
British Medical Bulletin, 1983 Grossman, A, Rees, L
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Opioid peptide precursors in striatum [PDF]
FEBS Letters, 1980 K.M. Metters +3 more
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, 1988 The discovery of endogenous opioids has begun an intricate saga involving multiple ligands and multiple receptors that form an extensive neuronal network in both the central and peripheral nervous systems. This intricacy is reflected in the complex pharmacology and diverse physiological effects of opioids in mammals.
Robert C. A. Frederickson +2 more
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Some of the next articles are maybe not open access.
Annual Review of Pharmacology and Toxicology, 1979
Opioid peptides are endogenous or synthetic peptides, with a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. The designation opioid peptide can be made if (a) it produces morphine-like, naloxone reversible effects in several in vitro bioassay sys tems such as the guinea pig ileum (1), the cat ...
and A Beaumont, John Hughes
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Opioid peptides are endogenous or synthetic peptides, with a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. The designation opioid peptide can be made if (a) it produces morphine-like, naloxone reversible effects in several in vitro bioassay sys tems such as the guinea pig ileum (1), the cat ...
and A Beaumont, John Hughes
openaire +2 more sources