Results 101 to 110 of about 54,057 (283)

IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics

Pharmacological Research, 2023
Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer, Christopher W. Cunningham   +1 more
doaj  

Underdiagnosis and impact of menstrual migraine in real‐world clinical practice: A real‐world survey

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This cross‐sectional study aimed to evaluate the frequency of menstrual migraine (MM) reporting in clinical practice and to compare the clinical burden, treatment patterns, and patient satisfaction between those with and without MM.
Gisela Terwindt, Jessica Ailani, Jessica Cirillo, Lucy Abraham, Aaron Jenkins, Phillip Saccone, Karin Hygge Blakeman, Feng Dai, James Jackson, Sophie Barlow, William Whitton, Lucy Hancock, Boryana Galabova   +12 more
wiley   +1 more source

Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin. [PDF]

, 1977
Menachem Rubinstein, S Stein, Sidney Udenfriend   +2 more
openalex   +1 more source

Reduction of opioid and barbiturate use following initiation of rimegepant for migraine in the United States

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen, Aaron Jenkins, Karin Hygge Blakeman, Feng Dai, Lucy Abraham, Chelsea Leroue, Josh Brown   +6 more
wiley   +1 more source

Influence of the hypothalamic arcuate nucleus on intraocular pressure and the role of opioid peptides.

PLoS ONE, 2014
BackgroundAn opioid peptide neuron/humoral feedback regulation might be involved in changes of intraocular pressure (IOP). The aims of this study are to investigate the effects of arcuate nucleus (ARC) and opioid peptides on intraocular pressure (IOP ...
Ji Jin, Guo-xu Xu, Zhi-lan Yuan
doaj   +1 more source

Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers-Possible Treatment Option? [PDF]

Cells, 2023
Guan Q, Velho RV, Jordan A, Pommer S, Radde I, Sehouli J, Mechsner S.   +6 more
europepmc   +1 more source

Differential behaviour of LPH‐(61–91)‐peptide in different model systems: Comparison of the opioid activities of LPH‐(61–91)‐peptide and its fragments [PDF]

, 1977
András Z. Rónai, László Gráf, József I. Székely, Zsuzsa Dunai-Kovàcs, S. Bajusz   +4 more
openalex   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

Molecules, 2019
Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression ...
Giulio Poli, Marilisa Pia Dimmito, Adriano Mollica, Gokhan Zengin, Sandor Benyhe, Ferenc Zador, Azzurra Stefanucci   +6 more
doaj   +1 more source

Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. [PDF]

Pharmaceutics, 2022
Zhang R, Chen M, Deng Z, Kong L, Shen B, Zhang L.   +5 more
europepmc   +1 more source