Results 111 to 120 of about 52,140 (266)
The Long Arc of Substance Use Policy Innovation in Medicaid: Looking Back, Looking Forward
The Milbank Quarterly, EarlyView.Policy Points The role of Medicaid in financing, organizing, and delivering substance use disorder (SUD) treatment has grown tremendously over time owing to expansions of eligibility and a push toward more uniformity in benefits. Current innovations in SUD treatment focus on expanding the delivery system to create a comprehensive continuum of care ...
BRENDAN SALONER
wiley +1 more source
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics
Pharmacological Research, 2023 Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer +1 more
doaj
Microscopy and spectroscopy approaches to study GPCR structure and function
British Journal of Pharmacology, EarlyView.Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl +2 more
wiley +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, EarlyView.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
PLoS ONE, 2014 BackgroundAn opioid peptide neuron/humoral feedback regulation might be involved in changes of intraocular pressure (IOP). The aims of this study are to investigate the effects of arcuate nucleus (ARC) and opioid peptides on intraocular pressure (IOP ...
Ji Jin, Guo-xu Xu, Zhi-lan Yuan
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Endogenous opioid peptides and the control of pain [PDF]
, 1979 H. W. Kosterlitz
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Molecules, 2019 Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression ...
Giulio Poli +6 more
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Opioid Atlas: Mapping Access to Pain Medication [PDF]
arXiv, 2016 Opiates are some of the most effective pain relief medications available for patients suffering from cancer and surgery-related pain. Despite the affordability and effectiveness of these medications, access to opiates is highly geographically variable. Pain researchers have attributed geographic variation to various factors including the fear of opioid
arxiv
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
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Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin. [PDF]
, 1977 Menachem Rubinstein +2 more
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