Results 111 to 120 of about 4,069 (216)

Neuroprotection for neonatal hypoxic–ischemic encephalopathy: A review of novel therapies evaluated in clinical studies

open access: yesDevelopmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.
Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan   +5 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone   +28 more
wiley   +1 more source

Survey on 9 years of anti‐doping controls in horse races in Italy

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Doping in racehorses is a threat to horse welfare and the integrity of the sport. Despite its relevance, the literature on the prevalence of anti‐doping violations worldwide is limited. Objectives To analyse anti‐doping violations in racehorses in Italy. Study Design Retrospective observational study.
Mariana Roccaro   +5 more
wiley   +1 more source

Release of bioactive peptides from whey proteins across digestion in adult humans and a static in vitro digestion model

open access: yesJournal of Functional Foods
Proteolysis of whey proteins during gastrointestinal digestion releases bioactive peptides with potential health benefits. Our study examined whey-derived peptide release after digestion under static in vitro conditions and in three adults following whey
Suwimon Sutantawong   +4 more
doaj  

Arrestin‐independent internalization of the GLP‐1 receptor is facilitated by a GRK, clathrin, and caveolae‐dependent mechanism

open access: yesThe FEBS Journal, Volume 292, Issue 7, Page 1675-1695, April 2025.
The glucagon‐like peptide‐1 (GLP‐1) receptor is regulated by distinct agonist‐induced and constitutive internalization pathways. Upon agonist stimulation, GLP‐1 receptor activates Gs and Gi/o, then recruits G protein–coupled receptor kinase 2/3/5/6 to phosphorylate the intracellular loops and C‐tail of the receptor.
Ee Von Moo   +4 more
wiley   +1 more source

d‐amino acids: new functional insights

open access: yesThe FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni   +5 more
wiley   +1 more source

Effects of a new opioid peptide (Tyr-Arg) on lamina V type neurons of the rabbit spinal dorsal horn

open access: gold, 1979
Masamichi Satoh   +3 more
openalex   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

open access: yesJournal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader   +2 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 899-941, May 2025.
HS treatment algorithm. Abstract Introduction This second part of the S2k guidelines is an update of the 2015 S1 European guidelines. Objective These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS ...
C. C. Zouboulis   +36 more
wiley   +1 more source

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