Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers-Possible Treatment Option? [PDF]
Cells, 2023 Guan Q +6 more
europepmc +1 more source
Discovering Opioid Use Patterns from Social Media for Relapse Prevention [PDF]
arXiv, 2019 The United States is currently experiencing an unprecedented opioid crisis, and opioid overdose has become a leading cause of injury and death. Effective opioid addiction recovery calls for not only medical treatments, but also behavioral interventions for impacted individuals.
arxiv
, 1997 Opioid peptides produced in the body act as neuromodulators that modify the actions of other neurotransmitters in the central nervous system. By altering the electrical properties of their target neurons, thereby making these neurons more difficult to ...
Froehlilch, Janice C.
core
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 Antinociceptive pathways are activated in the periphery in inflammatory pain, for instance resolvins and opioid peptides. Resolvins are biosynthesized from omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid ...
Beatrice Oehler +7 more
doaj +1 more source
Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. [PDF]
Pharmaceutics, 2022 Zhang R +5 more
europepmc +1 more source
SNARE based peptide linking as an efficient strategy to retarget botulinum neurotoxin’s enzymatic domain to specific neurons using diverse neuropeptides as targeting domains [PDF]
, 2011 Many disease states are caused by miss-regulated neurotransmission. A small fraction of these diseases can currently be treated with botulinum neurotoxin type A (BoNT/A).
, +6 more
core
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
A Survey of Molecular Imaging of Opioid Receptors
Molecules, 2019 The discovery of endogenous peptide ligands for morphine binding sites occurred in parallel with the identification of three subclasses of opioid receptor (OR), traditionally designated as μ, δ, and κ, along with the more recently defined ...
Paul Cumming +4 more
doaj +1 more source
Differential behaviour of LPH‐(61–91)‐peptide in different model systems: Comparison of the opioid activities of LPH‐(61–91)‐peptide and its fragments [PDF]
, 1977 András Z. Rónai +4 more
openalex +1 more source