A Comparison of Veterans with Problematic Opioid Use Identified through Natural Language Processing of Clinical Notes versus Using Diagnostic Codes [PDF]
arXivBackground: Electronic health records (EHRs) are a data source for opioid research. Opioid use disorder is known to be under-coded as a diagnosis, yet problematic opioid use can be documented in clinical notes. Objectives: Our goals were 1) to identify problematic opioid use from a full range of clinical notes; and 2) to compare the characteristics ...
arxiv
ENHANCING PERIPHERAL OPIOID ANALGESIA: DEVELOPMENT OF VIRAL VECTOR AND SMALL PEPTIDE THERAPIES [PDF]
, 2014 Chronic neuropathic pain often decreases quality of life, incurs high medical costs and is difficult to treat. Neuropathic pain can develop as a result of nerve damage induced by trauma or diseases such as diabetes and cancer.
Smith, Sherika
core +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Nociceptin/orphanin FQ neurons in the Arcuate Nucleus and Ventral Tegmental Area Act via Nociceptin Opioid Peptide Receptor Signaling to Inhibit Proopiomelanocortin and A10 Dopamine Neurons and Thereby Modulate Ingestion of Palatable Food. [PDF]
Physiol Behav, 2021 Hernandez J +5 more
europepmc +1 more source
Bibliometric Analysis of the 50 Most Cited Publications in Epidermolysis Bullosa
Pediatric Dermatology, EarlyView.ABSTRACT Epidermolysis bullosa (EB) is a group of inherited skin disorders characterized by extreme skin fragility, leading to recurrent blistering and significant impacts on patients' quality of life. A bibliometric analysis of the 50 most‐cited EB articles from the past six decades reveals that the majority of research focuses on understanding EB ...
Evelyn F. Fagan +4 more
wiley +1 more source
Journal of Functional FoodsProteolysis of whey proteins during gastrointestinal digestion releases bioactive peptides with potential health benefits. Our study examined whey-derived peptide release after digestion under static in vitro conditions and in three adults following whey
Suwimon Sutantawong +4 more
doaj
Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]
, 2001 To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P. +4 more
core
Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review
Analytical Science Advances, Volume 6, Issue 1, June 2025.ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry in recent years. Enabling the direct analysis of samples in their native state with neither sample preparation nor chromatographic separation provides chemical characterisation in a matter of seconds.
Alisha Henderson +2 more
wiley +1 more source
Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.
, 1977 Menachem Rubinstein +3 more
openalex +1 more source
An overview of the non‐procedural treatment options for peripheral neuropathic pain
Muscle &Nerve, Volume 71, Issue 5, Page 791-801, May 2025.Abstract Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology,
Evan R. Zeldin +6 more
wiley +1 more source