Results 161 to 170 of about 30,638 (285)

Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions

open access: yesMedComm, Volume 6, Issue 10, October 2025.
PROTACs are reshaping drug discovery through targeted protein degradation. Clinical programs now extend to prostate, breast, lung, hematologic, and solid tumors, with key targets including AR, ER, BTK, STAT3, Bcl‐xL, BRD9, Kras, and so on. These degraders overcome resistance, broaden therapeutic scope, and provide solutions for “undruggable” proteins ...
Gang Fan   +9 more
wiley   +1 more source

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li   +7 more
wiley   +1 more source

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications

open access: yesMedComm, Volume 6, Issue 10, October 2025.
Schematic diagram illustrating the comprehensive landscape of hydrogel microspheres (HMs). (A) The components of HMs. (B) Preparation technologies employed in fabricating HMs. (C) The diverse applications of HMs across different fields. (D) The therapeutic applications of HMs in the treatment of various systemic diseases, demonstrating their potential ...
Meng Yang   +14 more
wiley   +1 more source

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