Results 161 to 170 of about 1,142,563 (307)

Dynorphin–Still an Extraordinarily Potent Opioid Peptide

Molecular Pharmacology, 2013
C. Chavkin
semanticscholar   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Cocaine Self-administration Regulates Transcription of Opioid Peptide Precursors and Opioid Receptors in Rat Caudate Putamen and Prefrontal Cortex. [PDF]

Neuroscience, 2020
Sun H, Luessen DJ, Kind KO, Zhang K, Chen R.   +4 more
europepmc   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

Proceedings of the National Academy of Sciences of the United States of America, 2015
C. O’Connor, K. White, N. Doncescu, T. Didenko, B. Roth, G. Czaplicki, R. Stevens, K. Wüthrich, A. Milon   +8 more
semanticscholar   +1 more source

Exploratory Pain Profiling With Quantitative Sensory Testing (QST) in Episodic and Chronic Migraine

European Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic migraine (EM) and chronic migraine (CM) and investigate potential differences, given conflicting results ...
Rein F. van Welie, Floor C. van Welie, Jennifer P. Trouerbach‐Kraan, Albert Dahan, Monique van Velzen, Gisela M. Terwindt   +5 more
wiley   +1 more source

Peptide chirality and opioid receptor modulation: Hepatoprotective effect of d-Met-enkephalin in acetaminophen-induced liver injury

Acta Pharmaceutica
l-Met-enkephalin is a neuropeptide known to exert protective effects in various experimental models of autoimmune and inflammatory diseases. These effects are mediated through opioid receptors and can be abolished by the opioid receptor antagonist ...
Turčić Petra, Martinić Roko, Štambuk Nikola, Weitner Tin, Momčilović Mirna, Boban-Blagaić Alenka, Kos Marina, Stojković Ranko   +7 more
doaj   +1 more source

The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?

British Journal of Pharmacology, 2012
J. Yoo, I. Kitchen, A. Bailey
semanticscholar   +1 more source

Continuous production of a peptidic fraction containing the intermediate opioid peptide LVV‐haemorphin‐7 (LVVh‐7) by peptic hydrolysis of bovine haemoglobin in a continuous membrane reactor

, 2003
Romain Kapel, Rénato Froidevaux, Naïma Nedjar‐Arroume, Anne Fertin‐Bazus, Pascal Dhulster, Didier Guillochon   +5 more
openalex   +2 more sources

Hepatoprotective Effect of Morchella Mycelia Polysaccharides on Alcoholic Liver Injury and Its Mechanism Involving the Modulation of NOD‐Like Receptor Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The Morchella mycelium polysaccharide (MP), a homogeneous α‐glucan (96.555% glucose, 5.7 kDa), protects against alcohol‐induced liver injury in mice. It reduces serum ALT/AST, improves lipid metabolism, and enhances antioxidants and inhibiting lipid peroxidation. Mechanistically, the MP suppresses Nlrp3 inflammasome‐mediated inflammation/pyroptosis and
Xinyu Hu, Qinghu Duan, Leran Ma, Tianyuan Zhang, Mengdan Zhai, Zewei Chen, Wangqi Li, Kaiwen Huang, Yan Ma, Yuchen Zhang, Zhen Wang   +10 more
wiley   +1 more source