In vivo detection of optically-evoked opioid peptide release [PDF]
eLife, 2018 Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo.
Ream Al-Hasani +8 more
doaj +5 more sources
Involvement of the Opioid Peptide Family in Cancer Progression [PDF]
Biomedicines, 2023 Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez +2 more
doaj +2 more sources
Evaluation of [Cys(ATTO 488)8]Dermorphin-NH2 as a novel tool for the study of μ-opioid peptide receptors. [PDF]
PLoS ONE, 2021 The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant problems ...
Despina Giakomidi +9 more
doaj +2 more sources
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery [PDF]
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +2 more sources
An opioid-like system regulating feeding behavior in C. elegans [PDF]
eLife, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Mi Cheong Cheong +3 more
doaj +5 more sources
Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
Peter W. Schiller
openalex +5 more sources
Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord [PDF]
Nature CommunicationsItch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng +11 more
doaj +2 more sources
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor [PDF]
Nature CommunicationsThe endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li +10 more
doaj +2 more sources
The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets [PDF]
CellsThe presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa +6 more
doaj +2 more sources
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +14 more sources