Results 11 to 20 of about 1,142,563 (307)

Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells [PDF]

Life
Background: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice.
Moe Fukunaga, Shin Watanabe, Kanami Orihara, Naoyuki Yamamoto   +3 more
doaj   +2 more sources

Neuro-physiological characterization of opioid peptide actions on neurohumoral transmission in the mammalian central nervous system [PDF]

, 1986
W. Zieglgänsberger, Nicola Biagio Mercuri, Paolo Stanzione, Bernd Sutor   +3 more
openalex   +4 more sources

BN‐9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance‐forming antinociception in mice

British Journal of Pharmacology, 2016
Ning Li, Zheng-lan Han, Zi-long Wang, Yanhong Xing, Yu-long Sun, Xu-hui Li, Jingjing Song, Ting Zhang, Run Zhang, Meng‐na Zhang, Biao Xu, Quan Fang, Rui Wang   +12 more
semanticscholar   +2 more sources

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér, Kovács, Krisztina J., Milanes, Victoria M., Nunez, Cristina, Pintér-Kübler, Bernadett, Polyák, Ágnes, Zelei, Edina   +6 more
core   +14 more sources

Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

Molecules, 2023
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a ...
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin   +5 more
doaj   +1 more source

Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide

Biomolecules, 2020
The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration.
Anna Mas-Capdevila, Lisard Iglesias-Carres, Anna Arola-Arnal, Gerard Aragonès, Begoña Muguerza, Francisca Isabel Bravo   +5 more
doaj   +1 more source

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules, 2020
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt¹]DALDA, and KGOP01, Binding to the Mu Opioid Receptor

Molecules, 2020
The mu opioid receptor (MOR) is the primary target for analgesia of endogenous opioid peptides, alkaloids, synthetic small molecules with diverse scaffolds, and peptidomimetics.
Maria Dumitrascuta, Marcel Bermudez, Steven Ballet, Gerhard Wolber, Mariana Spetea   +4 more
doaj   +1 more source

Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview

Bioengineering, 2023
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected.
Nathalie Okdeh, Georges Mahfouz, Julien Harb, Jean-Marc Sabatier, Rabih Roufayel, Eddie Gazo Hanna, Hervé Kovacic, Ziad Fajloun   +7 more
doaj   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Molecules, 2021
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida   +12 more
doaj   +1 more source