Results 21 to 30 of about 52,140 (266)
CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture. [PDF]
PLoS ONE, 2014 Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pain, but molecular mechanisms remain largely enigmatic. In the early phase of inflammation neutrophilic chemokines direct opioid-containing neutrophils in the ...
Ying Wang +5 more
doaj +1 more source
Biomolecules, 2020 The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration.
Anna Mas-Capdevila +5 more
doaj +1 more source
LP1 and LP2: Dual-Target MOPr/DOPr Ligands as Drug Candidates for Persistent Pain Relief
Molecules, 2021 Although persistent pain is estimated to affect about 20% of the adult population, current treatments have poor results. Polypharmacology, which is the administration of more than one drug targeting on two or more different sites of action, represents a ...
Lorella Pasquinucci +5 more
doaj +1 more source
In vivo detection of optically-evoked opioid peptide release. [PDF]
Elife, 2018 Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo.
Al-Hasani R +8 more
europepmc +2 more sources
Molecules, 2020 The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt +7 more
doaj +1 more source
Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview
Bioengineering, 2023 Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected.
Nathalie Okdeh +7 more
doaj +1 more source
Molecules, 2021 Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa +12 more
doaj +1 more source
High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence. [PDF]
PLoS ONE, 2008 Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid ...
Hoau-Yan Wang +2 more
doaj +1 more source
An Engineered Endomorphin-2 Gene for Morphine Withdrawal Syndrome. [PDF]
PLoS ONE, 2016 An optimal therapeutics to manage opioid withdrawal syndrome is desired for opioid addiction treatment. Down-regulation of endogenous endomorphin-2 (EM2) level in the central nervous system after continuous morphine exposure was observed, which suggested
Fei-Xiang Wu +6 more
doaj +1 more source
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [PDF]
, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Celik, Melih O. +3 more
core +1 more source