Results 41 to 50 of about 54,402 (291)

Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. [PDF]

PLoS ONE, 2010
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins ...
Görel Sundström, Susanne Dreborg, Dan Larhammar   +2 more
doaj   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide

Experimental and Molecular Medicine, 2018
Pain medicine: Boosting the potency of opioid analgesics A hormone known to weaken the pain-relieving effects of opioid drugs does so because of interaction between the hormone receptor and the opioid receptor.
Yin Yang, Qian Li, Qi-Hua He, Ji-Sheng Han, Li Su, You Wan   +5 more
doaj   +1 more source

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]

, 2016
Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor, CARRADORI, Simone, Csaba To ̈mbo ̈ly, Erdei, Anna I., Ferenc O. ̈tvos, Ferenc Za ́dor, Fidanza, Lorenzo, Marzoli, Francesca, Mirzaie, Sako, MOLLICA, Adriano, MONTI, LUDOVICA, Moriello, Aniello Schiano, Novellino, Ettore, Petrocellis, Luciano De, PIERETTI, stefano, Samavati, Reza, STEFANUCCI, AZZURRA, Szabolcs Dvora ́csko, Szucs, Edina   +18 more
core   +1 more source

Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MS

Angewandte Chemie, EarlyView.
This study reveals a complex peptidomic landscape in the mouse somatosensory cortex, identifying locally released and potentially transported neuropeptides using a membrane‐free nanodialysis sampling probe coupled with nanoLC‐timsTOF mass spectrometry.
Keyin Li, Weihua Shi, Yanqi Tan, Yu Ding, Alex G. Armstrong, Yurii Vlasov, Jonathan V. Sweedler   +6 more
wiley   +2 more sources

Opioid peptides and metabolic regulation [PDF]

Diabetologia, 1988
La liaison entre opioides et obesite pourrait passer par des anomalies de l'insulino-secretion puisque une augmentation de la sensibilite des cellules B pancreatiques a la beta-endorphine a ete demontree chez les sujets obeses. Une profonde alteration du systeme opioide est presente dans le diabete sans que l'on puisse dire encore si cela represente un
GIUGLIANO, Dario, TORELLA R, LEFEBVRE PJ, D'ONOFRIO F.   +3 more
openaire   +4 more sources

Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders

Human Vaccines & Immunotherapeutics, 2019
Opioid use disorders (OUD) and fatal overdoses are a national emergency in the United States. Therapeutic vaccines offer a promising strategy to treat OUD and reduce the incidence of overdose.
Christine Robinson, Carly Baehr, Shirdi E. Schmiel, Claudia Accetturo, Daniel L. Mueller, Marco Pravetoni   +5 more
doaj   +1 more source

A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist

Molecules
Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba, Michael J. Ferracane, Thomas F. Murray, Jane V. Aldrich   +3 more
doaj   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
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